Antigen Peptide Transporter 2 (TAP2)

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ABC18; ABCB3; APT2; PSF2; RING11; Y1; ATP-binding cassette sub-family B member 3; Peptide supply factor 2; Peptide transporter involved in antigen processing 2

Antigen Peptide Transporter 2 (TAP2)
TAP2 is a a member of the superfamily of ATP-binding cassette (ABC) transporters. This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD112Hu01Recombinant Antigen Peptide Transporter 2 (TAP2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD112Hu01Polyclonal Antibody to Antigen Peptide Transporter 2 (TAP2)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Antigen Peptide Transporter 2 (TAP2)CLIA Kit Customized Service Offer
n/aELISA Kit for Antigen Peptide Transporter 2 (TAP2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Antigen Peptide Transporter 2 (TAP2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Antigen Peptide Transporter 2 (TAP2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Antigen Peptide Transporter 2 (TAP2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Antigen Peptide Transporter 2 (TAP2)CLIA Kit Customized Service Offer
n/aELISA Kit for Antigen Peptide Transporter 2 (TAP2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD112Ra01Recombinant Antigen Peptide Transporter 2 (TAP2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD112Ra01Polyclonal Antibody to Antigen Peptide Transporter 2 (TAP2)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Antigen Peptide Transporter 2 (TAP2)CLIA Kit Customized Service Offer
n/aELISA Kit for Antigen Peptide Transporter 2 (TAP2)ELISA Kit Customized Service Offer
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  2. "Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex."Proc. Natl. Acad. Sci. U.S.A. 89:1463-1467(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region."Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2."Immunogenetics 37:373-380(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome."Arthritis Rheum. 40:1685-1692(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Novel splicing of the human MHC-encoded peptide transporter confers unique properties."J. Immunol. 162:852-859(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain."Tissue Antigens 45:139-142(1995) [PubMed] [Europe PMC] [Abstract]
  11. "New TAP2 polymorphisms in Africans."Tissue Antigens 51:556-562(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis."Clin. Exp. Rheumatol. 12:29-33(1994) [PubMed] [Europe PMC] [Abstract]
  13. "A viral inhibitor of peptide transporters for antigen presentation."Nature 375:415-418(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site."J. Immunol. 157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47."EMBO J. 15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract]
  16. "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP."Immunity 6:613-621(1997) [PubMed] [Europe PMC] [Abstract]
  17. "The human cytomegalovirus gene product US6 inhibits ATP binding by TAP."EMBO J. 20:387-396(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Adenovirus E19 has two mechanisms for affecting class I MHC expression."J. Immunol. 162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation."J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Allelic variants of the human putative peptide transporter involved in antigen processing."Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract]
  22. "Homozygous human TAP peptide transporter mutation in HLA class I deficiency."Science 265:237-241(1994) [PubMed] [Europe PMC] [Abstract]
  23. "Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans."Genes Immun. 2:32-40(2001) [PubMed] [Europe PMC] [Abstract]