Collagen Type XIV (COL14)

Undulin is a large glycoprotein of the interstitial extracellular matrix. It is restricted to dense and soft connective tissues and is associated with mature collagen fibrils.Beginning at the N terminus, the predicted 1,780-amino acid undulin protein contains a putative signal peptide followed immediately by a fibronectin type III domain; a VWF A domain; 7 fibronectin type III domains; a second VWF A domain; and several collagenous and noncollagenous domains in the C-terminal region. The authors identified 2 additional 3-prime cDNAs; one of these may represent usage of an alternative polyadenylation signal and the other encodes a variant C-terminal noncollagenous domain. Bauer et al. (1997) stated that undulin is identical to collagen XIV. The human undulin proteins are 75% identical to chicken collagen XIV.