Desmoglein 4 (DSG4)

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CDGF13; CDHF13; LAH; Cadherin family member 13

Desmoglein 4 (DSG4)
Whittock and Bower (2003) identified and characterized, at the genetic level, a novel human desmoglein cDNA sharing homology with desmoglein-1 (DSG1), -2 (DSG2), and -3 (DSG3) and named it desmoglein-4 (DSG4). The 3.6-kb human DSG4 cDNA contains an open reading frame of 3,120 bp that encodes a precursor protein of 1,040 amino acids. The predicted mature protein comprises 991 amino acids with a molecular mass of 107,822 Da at pI 4.38. The human DSG4 protein shares 41%, 37%, and 50% sequence identity with human DSG1, DSG2, and DSG3, respectively. Using RT-PCR on multiple tissue cDNA samples, Whittock and Bower (2003) demonstrated that DSG4 has very specific tissue expression in salivary gland, testis, prostate, and skin.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Desmoglein 4 (DSG4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Desmoglein 4 (DSG4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Desmoglein 4 (DSG4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Desmoglein 4 (DSG4)CLIA Kit Customized Service Offer
n/aELISA Kit for Desmoglein 4 (DSG4)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Desmoglein 4 (DSG4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Desmoglein 4 (DSG4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Desmoglein 4 (DSG4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Desmoglein 4 (DSG4)CLIA Kit Customized Service Offer
n/aELISA Kit for Desmoglein 4 (DSG4)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Desmoglein 4 (DSG4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Desmoglein 4 (DSG4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Desmoglein 4 (DSG4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Desmoglein 4 (DSG4)CLIA Kit Customized Service Offer
n/aELISA Kit for Desmoglein 4 (DSG4)ELISA Kit Customized Service Offer
  1. "Desmoglein 4 in hair follicle differentiation and epidermal adhesion. Evidence from inherited hypotrichosis and acquired pemphigus vulgaris." Cell 113:249-260(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Genetic evidence for a novel human desmosomal cadherin, desmoglein 4."J. Invest. Dermatol. 120:523-530(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Experimental mouse model-passive transfer of nondesmoglein 1 and 3 antibodies for Pemphigus Vulgaris."(In) Chan L.S. (eds.);Animal models of human inflammatory skin diseases, pp.285-306, CRC Press, Boca Raton (2003)
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A recurrent intragenic deletion mutation in DSG4 gene in three Pakistani families with autosomal recessive hypotrichosis."J. Invest. Dermatol. 123:247-248(2004) [PubMed] [Europe PMC] [Abstract]