Cyclin Dependent Kinase 3 (CDK3)

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CDKN3; Cell division protein kinase 3

Cyclin Dependent Kinase 3 (CDK3)
Ye et al. (2001) reported the presence of a single point mutation in the CDK3 gene from several Mus musculus strains commonly used in the laboratory. This mutation results in the replacement of a conserved tryptophan (trp187) within kinase consensus domain IX with a stop codon. The protein predicted to be encoded by this allele was truncated near the T loop, which is involved in activation by CDK-activating kinase (CCNH). This mutation also deletes motif XI, known to be required for kinase function, and is therefore expected to generate a null allele. The mutation was missing in 2 wild-mice species. The data indicated that CDK3 is not required for M. musculus development and suggested that any functional role played by CDK3 in the G1/S-phase transition is likely to be redundant with another CDK.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cyclin Dependent Kinase 3 (CDK3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cyclin Dependent Kinase 3 (CDK3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cyclin Dependent Kinase 3 (CDK3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cyclin Dependent Kinase 3 (CDK3)CLIA Kit Customized Service Offer
n/aELISA Kit for Cyclin Dependent Kinase 3 (CDK3)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cyclin Dependent Kinase 3 (CDK3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cyclin Dependent Kinase 3 (CDK3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cyclin Dependent Kinase 3 (CDK3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cyclin Dependent Kinase 3 (CDK3)CLIA Kit Customized Service Offer
n/aELISA Kit for Cyclin Dependent Kinase 3 (CDK3)ELISA Kit Customized Service Offer
  1. "A family of human cdc2-related protein kinases."EMBO J. 11:2909-2917(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit."Genes Dev. 10:851-861(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Cyclin C/cdk3 promotes Rb-dependent G0 exit."Cell 117:239-251(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation."Cancer Res. 68:7650-7660(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]