Cytochrome C Oxidase Subunit I (COX1)

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MT-CO1; MTCO1; COI; COXI; Mitochondrially Encoded Cytochrome C Oxidase I; Cytochrome c oxidase polypeptide I

Cytochrome C Oxidase Subunit I (COX1)
MT-CO1 belongs to cytochrome c oxidase subunit I protein family. It is often used in DNA barcoding, because its mutation rate is often fast enough to distinguish closely related species. In most if not all seed plants, however, the rate of evolution of cox1 is very slow.
The enzyme complex consists of 3-4 subunits (prokaryotes) up to 13 polypeptides (mammals) of which only the catalytic subunit (equivalent to mammalian subunit I (CO I)) is found in all heme-copper respiratory oxidases. The presence of a bimetallic centre (formed by a high-spin heme and copper B) as well as a low-spin heme, both ligated to six conserved histidine residues near the outer side of four transmembrane spans within CO I is common to all family members.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cytochrome C Oxidase Subunit I (COX1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cytochrome C Oxidase Subunit I (COX1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cytochrome C Oxidase Subunit I (COX1)Polyclonal Antibody Customized Service Offer
Assay KitsSED283HuELISA Kit for Cytochrome C Oxidase Subunit I (COX1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cytochrome C Oxidase Subunit I (COX1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cytochrome C Oxidase Subunit I (COX1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cytochrome C Oxidase Subunit I (COX1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cytochrome C Oxidase Subunit I (COX1)CLIA Kit Customized Service Offer
n/aELISA Kit for Cytochrome C Oxidase Subunit I (COX1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cytochrome C Oxidase Subunit I (COX1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cytochrome C Oxidase Subunit I (COX1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cytochrome C Oxidase Subunit I (COX1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cytochrome C Oxidase Subunit I (COX1)CLIA Kit Customized Service Offer
n/aELISA Kit for Cytochrome C Oxidase Subunit I (COX1)ELISA Kit Customized Service Offer
  1. "Sequence and organization of the human mitochondrial genome."Nature 290:457-465(1981) [PubMed] [Europe PMC] [Abstract]
  2. "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs."Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J."Mol. Biol. Evol. 20:2132-2142(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Mitochondrial genome variation and the origin of modern humans."Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines."Genome Res. 13:1600-1606(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians."Int. J. Legal Med. 118:137-146(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing."J. Mol. Biol. 143:161-178(1980) [PubMed] [Europe PMC] [Abstract]
  8. "Heterogenous point mutations in the mitochondrial tRNA Ser(UCN) precursor coexisting with the A1555G mutation in deaf students from Mongolia."Am. J. Hum. Genet. 65:1803-1806(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Normal variants of human mitochondrial DNA and translation products: the building of a reference data base."Hum. Genet. 88:139-145(1991) [PubMed] [Europe PMC] [Abstract]
  10. "A mitochondrial DNA variant, identified in Leber hereditary optic neuropathy patients, which extends the amino acid sequence of cytochrome c oxidase subunit I."Am. J. Hum. Genet. 51:378-385(1992) [PubMed] [Europe PMC] [Abstract]
  11. "Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia."Blood 90:4961-4972(1997) [PubMed] [Europe PMC] [Abstract]
  12. "MtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase."Eur. J. Biochem. 258:132-138(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA."Neurology 55:644-649(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Metabolic consequences of a novel missense mutation of the mtDNA CO I gene."Hum. Mol. Genet. 11:1797-1805(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Introducing a novel human mtDNA mutation into the Paracoccus denitrificans COX I gene explains functional deficits in a patient."Neurogenetics 7:51-57(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission."Proc. Natl. Acad. Sci. U.S.A. 103:714-719(2006) [PubMed] [Europe PMC] [Abstract]
  17. "A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase."Proc. Natl. Acad. Sci. U.S.A. 106:3402-3407(2009) [PubMed] [Europe PMC] [Abstract]