Holocytochrome C Synthase (HCCS)

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CCHL; MCOPS7; Cytochrome C Heme-Lyase

Holocytochrome C Synthase (HCCS)
Based on its chromosomal location and its role in the mitochondrial respiratory chain, HCCS was considered a candidate gene for Rett syndrome (RTT). The genomic structure of the gene, which occupies an 11-kb region and consists of 7 exons, was determined. No mutational abnormality of the gene was found in 20 RTT patients (Van den Veyver et al., 1998).
The human gene, symbolized HCCS, and the corresponding murine gene characterized by Schaefer et al. (1996) share 83% nucleotide sequence identity and 85% amino acid identity. The authors stated that, because of the lack of a neuromuscular phenotype in MLS, it is uncertain how the deletion of a mitochondrial holocytochrome synthetase would contribute to the phenotype seen in MLS.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD310Hu01 Recombinant Holocytochrome C Synthase (HCCS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD310Hu01 Polyclonal Antibody to Holocytochrome C Synthase (HCCS) WB; IHC; ICC; IP.
MAD310Hu21 Monoclonal Antibody to Holocytochrome C Synthase (HCCS) WB; IHC; ICC; IP.
Assay Kits SED310Hu ELISA Kit for Holocytochrome C Synthase (HCCS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Holocytochrome C Synthase (HCCS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Holocytochrome C Synthase (HCCS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Holocytochrome C Synthase (HCCS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Holocytochrome C Synthase (HCCS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Holocytochrome C Synthase (HCCS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Holocytochrome C Synthase (HCCS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Holocytochrome C Synthase (HCCS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Holocytochrome C Synthase (HCCS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Holocytochrome C Synthase (HCCS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Holocytochrome C Synthase (HCCS) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a putative human holocytochrome c-type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS)."Genomics 34:166-172(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure of a human holocytochrome c-type synthetase gene in Xp22.3 and mutation analysis in patients with Rett syndrome."Am. J. Med. Genet. 78:179-181(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome."Am. J. Hum. Genet. 79:878-889(2006) [PubMed] [Europe PMC] [Abstract]