Glycogen Synthase 1, Muscle (GYS1)

[Edit]

GSY; Glycogen [starch] synthase, muscle

Glycogen Synthase 1, Muscle (GYS1)
GYS1 catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Glycogen synthase (UDP-glucose-glycogen glucosyltransferase') is a glycosyltransferase enzyme (EC 2.4.1.11) that catalyses the reaction of UDP-glucose and (1,4-α-D-glucosyl)n to yield UDP and (1,4-α-D-glucosyl)n+1.In other words, this enzyme converts excess glucose residues one by one into a polymeric chain for storage as glycogen. Its presence in the bloodstream is highest in the 30 to 60 minutes following intense exercise. It is a key enzyme in glycogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Glycogen Synthase 1, Muscle (GYS1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Glycogen Synthase 1, Muscle (GYS1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Glycogen Synthase 1, Muscle (GYS1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Glycogen Synthase 1, Muscle (GYS1)CLIA Kit Customized Service Offer
n/aELISA Kit for Glycogen Synthase 1, Muscle (GYS1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Glycogen Synthase 1, Muscle (GYS1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Glycogen Synthase 1, Muscle (GYS1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Glycogen Synthase 1, Muscle (GYS1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Glycogen Synthase 1, Muscle (GYS1)CLIA Kit Customized Service Offer
n/aELISA Kit for Glycogen Synthase 1, Muscle (GYS1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Glycogen Synthase 1, Muscle (GYS1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Glycogen Synthase 1, Muscle (GYS1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Glycogen Synthase 1, Muscle (GYS1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Glycogen Synthase 1, Muscle (GYS1)CLIA Kit Customized Service Offer
n/aELISA Kit for Glycogen Synthase 1, Muscle (GYS1)ELISA Kit Customized Service Offer
  1. "Human muscle glycogen synthase cDNA sequence: a negatively charged protein with an asymmetric charge distribution."Proc. Natl. Acad. Sci. U.S.A. 86:1443-1447(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of the human muscle glycogen synthase gene."Diabetes 44:1099-1105(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of a glycogen synthase cDNA from human endometrium."J. Steroid Biochem. Mol. Biol. 59:459-465(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Control of mammalian glycogen synthase by PAS kinase."Proc. Natl. Acad. Sci. U.S.A. 102:16596-16601(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction between glycogenin and glycogen synthase."Arch. Biochem. Biophys. 456:93-97(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Cardiomyopathy and exercise intolerance in muscle glycogen storage disease 0."N. Engl. J. Med. 357:1507-1514(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals."J. Neurochem. 118:596-610(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]