Mammary Serine Protease Inhibitor (Maspin)

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SERPINB5; PI5; Protease Inhibitor 5; Serpin Peptidase Inhibitor Clade B Member 5

Mammary Serine Protease Inhibitor (Maspin)
Maspin is a serpin and tumor suppressor gene.It has been associated with prostate cancer and breast cancer.It has also been associated with tumors of the pancreas.It was identified in 1994.In normal cells expressing SERPINB5, the SERPINB5 promoter is unmethylated and the promoter region has acetylated histones and an accessible chromatin structure. In contrast, normal cells that do not express SERPINB5 have a completely methylated SERPINB5 promoter with hypoacetylated histones, an inaccessible chromatin structure, and a transcriptional repression that is relieved by inhibition of DNA methylation. These findings indicated that cytosine methylation is important in the establishment and maintenance of cell type-restricted gene expression.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD386Hu01Recombinant Mammary Serine Protease Inhibitor (Maspin)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD386Hu01Polyclonal Antibody to Mammary Serine Protease Inhibitor (Maspin)WB, ICC, IHC-P, IHC-F, ELISA
MAD386Hu21Monoclonal Antibody to Mammary Serine Protease Inhibitor (Maspin)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSED386HuELISA Kit for Mammary Serine Protease Inhibitor (Maspin)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Mammary Serine Protease Inhibitor (Maspin)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Mammary Serine Protease Inhibitor (Maspin)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Mammary Serine Protease Inhibitor (Maspin)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Mammary Serine Protease Inhibitor (Maspin)CLIA Kit Customized Service Offer
n/aELISA Kit for Mammary Serine Protease Inhibitor (Maspin)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Mammary Serine Protease Inhibitor (Maspin)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Mammary Serine Protease Inhibitor (Maspin)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Mammary Serine Protease Inhibitor (Maspin)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Mammary Serine Protease Inhibitor (Maspin)CLIA Kit Customized Service Offer
n/aELISA Kit for Mammary Serine Protease Inhibitor (Maspin)ELISA Kit Customized Service Offer
  1. "Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells."Science 263:526-529(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin."J. Biol. Chem. 270:15832-15837(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership."J. Biol. Chem. 280:34210-34217(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix."J. Biol. Chem. 280:22356-22364(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]