Heparanase 2 (HPA2)

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HPSE2; HPR2; Inactive heparanase-2

Heparanase 2 (HPA2)
Heparanase-2 is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants.
Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti-cancer therapies.Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Heparanase 2 (HPA2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Heparanase 2 (HPA2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Heparanase 2 (HPA2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Heparanase 2 (HPA2)CLIA Kit Customized Service Offer
n/aELISA Kit for Heparanase 2 (HPA2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Heparanase 2 (HPA2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Heparanase 2 (HPA2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Heparanase 2 (HPA2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Heparanase 2 (HPA2)CLIA Kit Customized Service Offer
n/aELISA Kit for Heparanase 2 (HPA2)ELISA Kit Customized Service Offer
  1. "Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member."Biochem. Biophys. Res. Commun. 276:1170-1177(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Loss-of-function mutations in HPSE2 cause the autosomal recessive urofacial syndrome."Am. J. Hum. Genet. 86:957-962(2010) [PubMed] [Europe PMC] [Abstract]
  4. ErratumAm. J. Hum. Genet. 87:161-161(2010)
  5. "Mutations in HPSE2 cause urofacial syndrome." Am. J. Hum. Genet. 86:963-969(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity."J. Biol. Chem. 285:28010-28019(2010) [PubMed] [Europe PMC] [Abstract]