Cytochrome P450 24A1 (CYP24A1)

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CP24; CYP24; P450-CC24; Vitamin D 24-Hydroxylase; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial ; Cytochrome P450 Family 24 Subfamily A Polypeptide 1

Cytochrome P450 24A1 (CYP24A1)
CYP24A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain to form calcitroic acid.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD543Hu01Recombinant Cytochrome P450 24A1 (CYP24A1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD543Hu01Polyclonal Antibody to Cytochrome P450 24A1 (CYP24A1)WB, ICC, IHC-P, IHC-F, ELISA
MAD543Hu21Monoclonal Antibody to Cytochrome P450 24A1 (CYP24A1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSED543HuELISA Kit for Cytochrome P450 24A1 (CYP24A1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD543Mu01Recombinant Cytochrome P450 24A1 (CYP24A1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD543Mu01Polyclonal Antibody to Cytochrome P450 24A1 (CYP24A1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Cytochrome P450 24A1 (CYP24A1)CLIA Kit Customized Service Offer
n/aELISA Kit for Cytochrome P450 24A1 (CYP24A1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cytochrome P450 24A1 (CYP24A1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cytochrome P450 24A1 (CYP24A1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cytochrome P450 24A1 (CYP24A1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cytochrome P450 24A1 (CYP24A1)CLIA Kit Customized Service Offer
n/aELISA Kit for Cytochrome P450 24A1 (CYP24A1)ELISA Kit Customized Service Offer
  1. "Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA."Proc. Natl. Acad. Sci. U.S.A. 90:4543-4547(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis."J. Biol. Chem. 280:20604-20611(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements."Biochim. Biophys. Acta 1263:1-9(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets."J. Bone Miner. Res. 8:1397-1406(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Metabolism of vitamin D3 by cytochromes P450."Front. Biosci. 10:119-134(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in CYP24A1 and idiopathic infantile hypercalcemia."N. Engl. J. Med. 365:410-421(2011) [PubMed] [Europe PMC] [Abstract]