ATP Binding Cassette Transporter C9 (ABCC9)

[Edit]

ABC-C9; SUR2; ABC37; CMD1O; Sulfonylurea receptor 2

ATP Binding Cassette Transporter C9 (ABCC9)
ABCC9 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD629Hu01Recombinant ATP Binding Cassette Transporter C9 (ABCC9)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD629Hu01Polyclonal Antibody to ATP Binding Cassette Transporter C9 (ABCC9)WB, ICC, IHC-P, IHC-F, ELISA
MAD629Hu21Monoclonal Antibody to ATP Binding Cassette Transporter C9 (ABCC9)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSED629HuELISA Kit for ATP Binding Cassette Transporter C9 (ABCC9)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant ATP Binding Cassette Transporter C9 (ABCC9)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to ATP Binding Cassette Transporter C9 (ABCC9)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to ATP Binding Cassette Transporter C9 (ABCC9)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for ATP Binding Cassette Transporter C9 (ABCC9)CLIA Kit Customized Service Offer
n/aELISA Kit for ATP Binding Cassette Transporter C9 (ABCC9)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant ATP Binding Cassette Transporter C9 (ABCC9)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to ATP Binding Cassette Transporter C9 (ABCC9)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to ATP Binding Cassette Transporter C9 (ABCC9)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for ATP Binding Cassette Transporter C9 (ABCC9)CLIA Kit Customized Service Offer
n/aELISA Kit for ATP Binding Cassette Transporter C9 (ABCC9)ELISA Kit Customized Service Offer
  1. "Toward understanding the assembly and structure of KATP channels."Physiol. Rev. 78:227-245(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells."Circ. Res. 83:1132-1143(1998) [PubMed] [Europe PMC] [Abstract]
  4. "A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila." Mol. Psychiatry 18:122-132(2013) [PubMed] [Europe PMC] [Abstract]
  5. "ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating."Nat. Genet. 36:382-387(2004) [PubMed] [Europe PMC] [Abstract]
  6. "KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation."Nat. Clin. Pract. Cardiovasc. Med. 4:110-116(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Cantu syndrome is caused by mutations in ABCC9." Am. J. Hum. Genet. 90:1094-1101(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Dominant missense mutations in ABCC9 cause Cantu syndrome." Nat. Genet. 44:793-796(2012) [PubMed] [Europe PMC] [Abstract]