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ATP Binding Cassette Transporter A7 (ABCA7)

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ABC-A7; ABCA-SSN; ABCX; Autoantigen SS-N; Macrophage ABC transporter

ATP Binding Cassette Transporter A7 (ABCA7)
CCC D647
HGNC 37
MGI 1351646
PubMed 14592415
RGD 1303134
UniProt Q8IZY2
Wiki ABCA7
ABCA7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, CFTR/MRP, ALD (adrenoleukodystrophy), OABP, GCN20, and White. This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD647Hu01 Recombinant ATP Binding Cassette Transporter A7 (ABCA7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD647Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter A7 (ABCA7) WB; IHC; ICC; IP.
Assay Kits SED647Hu ELISA Kit for ATP Binding Cassette Transporter A7 (ABCA7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter A7 (ABCA7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter A7 (ABCA7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter A7 (ABCA7) Polyclonal Antibody Customized Service Offer
Assay Kits SED647Mu ELISA Kit for ATP Binding Cassette Transporter A7 (ABCA7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter A7 (ABCA7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter A7 (ABCA7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter A7 (ABCA7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter A7 (ABCA7) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter A7 (ABCA7) ELISA Kit Customized Service Offer
  1. "Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)."Biochem. Biophys. Res. Commun. 273:532-538(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene."Biochem. Biophys. Res. Commun. 278:782-789(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's Syndrome."Biochem. Biophys. Res. Commun. 283:1019-1025(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter."Cytogenet. Cell Genet. 92:264-270(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release."Biochem. Biophys. Res. Commun. 311:313-318(2003) [PubMed] [Europe PMC] [Abstract]
  7. "ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux."J. Biol. Chem. 278:42906-42912(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization."J. Invest. Dermatol. 121:465-474(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein."J. Biol. Chem. 279:604-611(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8."J. Hum. Genet. 47:285-310(2002) [PubMed] [Europe PMC] [Abstract]