ATP Binding Cassette Transporter G5 (ABCG5)

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ABC-G5; STSL; Sterolin 1; ATP-binding cassette sub-family G member 5

ATP Binding Cassette Transporter G5 (ABCG5)
ABCG5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant ATP Binding Cassette Transporter G5 (ABCG5)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to ATP Binding Cassette Transporter G5 (ABCG5)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to ATP Binding Cassette Transporter G5 (ABCG5)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for ATP Binding Cassette Transporter G5 (ABCG5)CLIA Kit Customized Service Offer
n/aELISA Kit for ATP Binding Cassette Transporter G5 (ABCG5)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD655Mu01Recombinant ATP Binding Cassette Transporter G5 (ABCG5)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD655Mu01Polyclonal Antibody to ATP Binding Cassette Transporter G5 (ABCG5)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for ATP Binding Cassette Transporter G5 (ABCG5)CLIA Kit Customized Service Offer
n/aELISA Kit for ATP Binding Cassette Transporter G5 (ABCG5)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant ATP Binding Cassette Transporter G5 (ABCG5)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to ATP Binding Cassette Transporter G5 (ABCG5)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to ATP Binding Cassette Transporter G5 (ABCG5)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for ATP Binding Cassette Transporter G5 (ABCG5)CLIA Kit Customized Service Offer
n/aELISA Kit for ATP Binding Cassette Transporter G5 (ABCG5)ELISA Kit Customized Service Offer
  1. "Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters."Science 290:1771-1775(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption."Nat. Genet. 27:79-83(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively."Am. J. Hum. Genet. 69:278-290(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Role of ABCG1 and other ABCG family members in lipid metabolism."J. Lipid Res. 42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia."Hum. Mutat. 18:359-360(2001) [PubMed] [Europe PMC] [Abstract]