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Regulator of G-protein signalling 9 is a protein involved in regulation of signal transduction inside cells. Members of the RGS family, such as RGS9, are signaling proteins that suppress the activity of G proteins by promoting their deactivation.
There are two splice isoforms of RGS9 with quite different properties and patterns of expression. RGS9-1 is mainly found in the eye and is involved in regulation of phototransduction in rod and cone cells of the retina, while RGS9-2 is found in the brain, and regulates dopamine and opioid signaling in the basal ganglia. This means that any targeting of RGS9 as a therapeutic target must be able to distinguish between these different tissue isoforms in order to avoid affecting vision.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD699Hu01 | Recombinant Regulator Of G Protein Signaling 9 (RGS9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD699Hu01 | Polyclonal Antibody to Regulator Of G Protein Signaling 9 (RGS9) | WB; IHC; ICC; IP. |
| Assay Kits | SED699Hu | ELISA Kit for Regulator Of G Protein Signaling 9 (RGS9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD699Mu01 | Recombinant Regulator Of G Protein Signaling 9 (RGS9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD699Mu01 | Polyclonal Antibody to Regulator Of G Protein Signaling 9 (RGS9) | WB; IHC; ICC; IP. |
| Assay Kits | SED699Mu | ELISA Kit for Regulator Of G Protein Signaling 9 (RGS9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Regulator Of G Protein Signaling 9 (RGS9) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Regulator Of G Protein Signaling 9 (RGS9) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Regulator Of G Protein Signaling 9 (RGS9) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SED699Ra | ELISA Kit for Regulator Of G Protein Signaling 9 (RGS9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Molecular characterization of human and rat RGS9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS9 gene."Mol. Pharmacol. 54:687-694(1998) [PubMed] [Europe PMC] [Abstract]
- "Structure, alternative splicing, and expression of the human RGS9 gene."Gene 240:23-34(1999) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
- "The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo."J. Neurosci. 23:10175-10181(2003) [PubMed] [Europe PMC] [Abstract]
- "Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation."Nature 427:75-78(2004) [PubMed] [Europe PMC] [Abstract]