Protein Disulfide Isomerase A6 (PDIA6)

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PDI-A6; TXNDC7; P5; ERp5; Thioredoxin Domain Containing 7(Protein Disulfide Isomerase); Protein Disulfide Isomerase-Associated 6; Endoplasmic reticulum protein 5

Protein Disulfide Isomerase A6 (PDIA6)
Protein disulfide isomerases, such as PDIA6, are endoplasmic reticulum resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins The deduced 440-amino acid protein has a calculated molecular mass of 48.1 kD. It has a putative N-terminal signal sequence, followed by 2 thioredoxin like domains and a C-terminal ER retention signal. Mutation analysis revealed that the first thioredoxin-like motif of P5 was more important than the second for isomerase activity, and that the first cysteine in each motif was necessary for isomerase activity. Thioredoxin motif mutants of P5 lacking isomerase activity retained chaperone activity with citrate synthase as substrate, indicating that, like PDI, the isomerase and chaperone activities of P5 are likely independent.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD776Hu01Recombinant Protein Disulfide Isomerase A6 (PDIA6)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD776Hu01Polyclonal Antibody to Protein Disulfide Isomerase A6 (PDIA6)WB, ICC, IHC-P, IHC-F, ELISA
MAD776Hu21Monoclonal Antibody to Protein Disulfide Isomerase A6 (PDIA6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSED776HuELISA Kit for Protein Disulfide Isomerase A6 (PDIA6)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Protein Disulfide Isomerase A6 (PDIA6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Protein Disulfide Isomerase A6 (PDIA6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Protein Disulfide Isomerase A6 (PDIA6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Protein Disulfide Isomerase A6 (PDIA6)CLIA Kit Customized Service Offer
n/aELISA Kit for Protein Disulfide Isomerase A6 (PDIA6)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Protein Disulfide Isomerase A6 (PDIA6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Protein Disulfide Isomerase A6 (PDIA6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Protein Disulfide Isomerase A6 (PDIA6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Protein Disulfide Isomerase A6 (PDIA6)CLIA Kit Customized Service Offer
n/aELISA Kit for Protein Disulfide Isomerase A6 (PDIA6)ELISA Kit Customized Service Offer
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  6. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
  7. "A role for the thiol isomerase protein ERP5 in platelet function."Blood 105:1500-1507(2005) [PubMed] [Europe PMC] [Abstract]