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Thrombospondin 4 (THBS4)

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TSP4

Thrombospondin 4 (THBS4)
CCC D824
HGNC 11788
MGI 1101779
PubMed 23420636
RGD 62046
UniProt P35443
Wiki THBS4
Thrombospondin 4 (THBS4) was originally identified from a Xenopus stage 45 cDNA library.Overall, the 961-amino acid predicted protein is 73% identical to the X. laevis sequence; however, the C-terminal 220 residues are over 92% identical. The TSP4 mRNA is approximately 3.4 kb. In contrast to thrombospondin-4 of Xenopus laevis, the human protein contains an RGD (arg-gly-asp) cell-binding sequence in the third type 3 repeat.
Transfection of mouse NIH 3T3 fibroblasts or C2C12 myoblasts with a full-length human thrombospondin-4 cDNA resulted in the expression of a polypeptide with a reduced molecular weight of 140,000. In the absence of reducing agent, the expressed protein had an apparent molecular weight of 550,000.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD824Hu01 Recombinant Thrombospondin 4 (THBS4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD824Hu01 Polyclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC; IP.
LAD824Hu81 FITC-Linked Polyclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC; IF.
LAD824Hu71 Biotin-Linked Polyclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC.
MAD824Hu21 Monoclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC; IP.
Assay Kits SED824Hu ELISA Kit for Thrombospondin 4 (THBS4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD824Mu01 Recombinant Thrombospondin 4 (THBS4) Positive Control; Immunogen; SDS-PAGE; WB.
RPD824Mu02 Recombinant Thrombospondin 4 (THBS4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD824Mu01 Polyclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC; IP.
LAD824Mu81 FITC-Linked Polyclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC; IF.
LAD824Mu71 Biotin-Linked Polyclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC.
PAD824Mu02 Polyclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC; IP.
Assay Kits SED824Mu ELISA Kit for Thrombospondin 4 (THBS4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD824Ra01 Recombinant Thrombospondin 4 (THBS4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD824Ra01 Polyclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC; IP.
LAD824Ra81 FITC-Linked Polyclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC; IF.
LAD824Ra71 Biotin-Linked Polyclonal Antibody to Thrombospondin 4 (THBS4) WB; IHC; ICC.
Assay Kits SED824Ra ELISA Kit for Thrombospondin 4 (THBS4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The evolution of the thrombospondin gene family."J. Mol. Evol. 36:509-516(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of human thrombospondin-4."J. Biol. Chem. 270:2809-2814(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Regulator of differentiation 1 (ROD1) binds to the amphipathic C-terminal peptide of thrombospondin-4 and is involved in its mitogenic activity."J. Cell. Physiol. 220:672-679(2009) [PubMed] [Europe PMC] [Abstract]
  6. "A thrombospondin-dependent pathway for a protective ER stress response."Cell 149:1257-1268(2012) [PubMed] [Europe PMC] [Abstract]
  7. "ATF6 [corrected] and thrombospondin 4: the dynamic duo of the adaptive endoplasmic reticulum stress response."Circ. Res. 112:9-12(2013) [PubMed] [Europe PMC] [Abstract]
  8. ErratumCirc. Res. 112:E31-E31(2013)
  9. "Thrombospondins: old players, new games."Curr. Opin. Lipidol. 24:401-409(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels."Thromb. Haemost. 106:1170-1178(2011) [PubMed] [Europe PMC] [Abstract]