General Transcription Factor IIH, Polypeptide 5 (GTF2H5)

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TTD; TFB5; TGF2H5; TTD-A; TTDA; C6orf175; DNA Repair Syndrome Trichothiodystrophy Group A; TFIIH basal transcription factor complex TTD-A subunit

General Transcription Factor IIH, Polypeptide 5 (GTF2H5)
General Transcription Factor IIH,Polypeptide 5 is a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and is implicated in regulating cellular levels of TFIIH. Mutations in this gene result in trichothiodystrophy, complementation group A.
This protein, called TFB5, is a core component of yeast general transcription and DNA repair factor IIH (TFIIH). Database screening identified a human homolog of 71 amino acids that shares 28% identity with the yeast protein. Giglia-Mari et al. (2004) cloned the human cDNA corresponding to the TFB5 gene from primary fibroblasts.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD900Hu01 Recombinant General Transcription Factor IIH, Polypeptide 5 (GTF2H5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD900Hu01 Polyclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5) CLIA Kit Customized Service Offer
n/a ELISA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant General Transcription Factor IIH, Polypeptide 5 (GTF2H5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5) CLIA Kit Customized Service Offer
n/a ELISA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant General Transcription Factor IIH, Polypeptide 5 (GTF2H5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5) CLIA Kit Customized Service Offer
n/a ELISA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5) ELISA Kit Customized Service Offer
  1. "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A and stabilizes TFIIH."Nat. Genet. 36:714-719(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Crystal structure of the human TFIIH."Submitted (FEB-2005) to the PDB data bank