General Transcription Factor IIH, Polypeptide 5 (GTF2H5)

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TTD; TFB5; TGF2H5; TTD-A; TTDA; C6orf175; DNA Repair Syndrome Trichothiodystrophy Group A; TFIIH basal transcription factor complex TTD-A subunit

General Transcription Factor IIH, Polypeptide 5 (GTF2H5)
General Transcription Factor IIH,Polypeptide 5 is a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and is implicated in regulating cellular levels of TFIIH. Mutations in this gene result in trichothiodystrophy, complementation group A.
This protein, called TFB5, is a core component of yeast general transcription and DNA repair factor IIH (TFIIH). Database screening identified a human homolog of 71 amino acids that shares 28% identity with the yeast protein. Giglia-Mari et al. (2004) cloned the human cDNA corresponding to the TFB5 gene from primary fibroblasts.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD900Hu01Recombinant General Transcription Factor IIH, Polypeptide 5 (GTF2H5)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD900Hu01Polyclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5)CLIA Kit Customized Service Offer
n/aELISA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant General Transcription Factor IIH, Polypeptide 5 (GTF2H5)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5)CLIA Kit Customized Service Offer
n/aELISA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant General Transcription Factor IIH, Polypeptide 5 (GTF2H5)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5)CLIA Kit Customized Service Offer
n/aELISA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5)ELISA Kit Customized Service Offer
  1. "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A and stabilizes TFIIH."Nat. Genet. 36:714-719(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Crystal structure of the human TFIIH."Submitted (FEB-2005) to the PDB data bank