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Protein Arginine Methyltransferase 1 (PRMT1)

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ANM1; HCP1; HRMT1L2; IR1B4; Histone-arginine N-methyltransferase PRMT1; Interferon receptor 1-bound protein 4

Protein Arginine Methyltransferase 1 (PRMT1)
CCC D991
HGNC 5187
MGI 107846
PubMed 18316480
RGD 62020
UniProt Q99873
Wiki PRMT1
Protein arginine methylation is catalyzed by arginine methyltransferases. The bulk of methylated arginine residues in eukaryotic cells are found in heterogeneous nuclear ribonucleoproteins (hnRNPs), RNA-binding proteins that play essential roles in the metabolism of nuclear pre-mRNA. Recombinant PRMT1 methylated histones and hnRNPA1 in vitro. The deduced 361-amino acid protein was designated IR1B4 for 'interferon receptor-1-bound protein 4.' Epitope-tagged IR1B4 bound the IFNAR1 intracytoplasmic domain in vitro. Antibodies against IFNAR1 coimmunoprecipitated a methyltransferase activity from human cell extracts. An antisense oligonucleotide strongly reduced methyltransferase activity in human cells, and caused them to become more resistant to growth inhibition by interferon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD991Hu01 Recombinant Protein Arginine Methyltransferase 1 (PRMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Protein Arginine Methyltransferase 1 (PRMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Arginine Methyltransferase 1 (PRMT1) Polyclonal Antibody Customized Service Offer
Assay Kits SED991Hu ELISA Kit for Protein Arginine Methyltransferase 1 (PRMT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD991Mu01 Recombinant Protein Arginine Methyltransferase 1 (PRMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Protein Arginine Methyltransferase 1 (PRMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Arginine Methyltransferase 1 (PRMT1) Polyclonal Antibody Customized Service Offer
Assay Kits SED991Mu ELISA Kit for Protein Arginine Methyltransferase 1 (PRMT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Arginine Methyltransferase 1 (PRMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Arginine Methyltransferase 1 (PRMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Arginine Methyltransferase 1 (PRMT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Arginine Methyltransferase 1 (PRMT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Arginine Methyltransferase 1 (PRMT1) ELISA Kit Customized Service Offer
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  2. "Structural and functional conservation of human and yeast HCP1 genes which can suppress the growth defect of the Saccharomyces cerevisiae ire15 mutant."Gene 171:107-111(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene."Biochem. Biophys. Res. Commun. 278:349-359(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3."J. Biol. Chem. 275:19866-19876(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The structure and oligomerization of the yeast arginine methyltransferase, Hmt1."Nat. Struct. Biol. 7:1165-1171(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1."Curr. Biol. 11:996-1000(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor."Science 293:853-857(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties."Mol. Cell 11:1055-1066(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of estrogen rapid signaling through arginine methylation by PRMT1."Mol. Cell 31:212-221(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt."Mol. Cell 32:221-231(2008) [PubMed] [Europe PMC] [Abstract]
  14. "PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells."Neurosci. Lett. 445:162-165(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state."Proteins 72:1125-1137(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4."Biochem. J. 421:253-261(2009) [PubMed] [Europe PMC] [Abstract]
  17. "PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function."Exp. Cell Res. 315:1273-1286(2009) [PubMed] [Europe PMC] [Abstract]
  18. "PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling."Genes Dev. 23:118-132(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells."J. Biol. Chem. 285:20595-20606(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]