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Neurofilament, Heavy Polypeptide (NEFH)

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NFH; 200 kDa neurofilament protein; Neurofilament triplet H protein

Neurofilament, Heavy Polypeptide (NEFH)
CCC E037
HGNC 7737
MGI 97309
RGD 3159
UniProt P12036
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein.
NEFH is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE037Hu01 Recombinant Neurofilament, Heavy Polypeptide (NEFH) Positive Control; Immunogen; SDS-PAGE; WB.
RPE037Hu02 Recombinant Neurofilament, Heavy Polypeptide (NEFH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE037Hu21 Monoclonal Antibody to Neurofilament, Heavy Polypeptide (NEFH) WB; IHC; ICC; IP.
PAE037Hu01 Polyclonal Antibody to Neurofilament, Heavy Polypeptide (NEFH) WB; IHC; ICC; IP.
Assay Kits SEE037Hu ELISA Kit for Neurofilament, Heavy Polypeptide (NEFH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE037Mu01 Recombinant Neurofilament, Heavy Polypeptide (NEFH) Positive Control; Immunogen; SDS-PAGE; WB.
EPE037Mu61 Eukaryotic Neurofilament, Heavy Polypeptide (NEFH) Positive Control; Immunogen; SDS-PAGE; WB.
APE037Mu61 Active Neurofilament, Heavy Polypeptide (NEFH) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Neurofilament, Heavy Polypeptide (NEFH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurofilament, Heavy Polypeptide (NEFH) Polyclonal Antibody Customized Service Offer
Assay Kits SEE037Mu ELISA Kit for Neurofilament, Heavy Polypeptide (NEFH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE037Ra01 Recombinant Neurofilament, Heavy Polypeptide (NEFH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE037Ra21 Monoclonal Antibody to Neurofilament, Heavy Polypeptide (NEFH) WB; IHC; ICC; IP.
PAE037Ra01 Polyclonal Antibody to Neurofilament, Heavy Polypeptide (NEFH) WB; IHC; ICC; IP.
Assay Kits SEE037Ra ELISA Kit for Neurofilament, Heavy Polypeptide (NEFH) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it."EMBO J. 7:1947-1955(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular Cloning of human hSTE cDNA."Beijing Yi Ke Da Xue Xue Bao 31:531-531(1999)
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "PKN associates and phosphorylates the head-rod domain of neurofilament protein."J. Biol. Chem. 271:9816-9822(1996) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis."Hum. Mol. Genet. 3:1757-1761(1994) [PubMed] [Europe PMC] [Abstract]