Ephrin Type B Receptor 4 (EPHB4)

[Edit]

HTK; MYK1; TYRO11; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11

Ephrin Type B Receptor 4 (EPHB4)
Ephrin type-B receptor 4 is a protein encoded by the EPHB4 gene.Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ephrin Type B Receptor 4 (EPHB4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ephrin Type B Receptor 4 (EPHB4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ephrin Type B Receptor 4 (EPHB4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ephrin Type B Receptor 4 (EPHB4)CLIA Kit Customized Service Offer
n/aELISA Kit for Ephrin Type B Receptor 4 (EPHB4)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ephrin Type B Receptor 4 (EPHB4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ephrin Type B Receptor 4 (EPHB4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ephrin Type B Receptor 4 (EPHB4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ephrin Type B Receptor 4 (EPHB4)CLIA Kit Customized Service Offer
n/aELISA Kit for Ephrin Type B Receptor 4 (EPHB4)ELISA Kit Customized Service Offer
  1. "Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily."J. Biol. Chem. 269:14211-14218(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Unified nomenclature for Eph family receptors and their ligands, the ephrins."Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells."J. Cell Sci. 116:2461-2470(2003) [PubMed] [Europe PMC] [Abstract]
  7. "EphB4 controls blood vascular morphogenesis during postnatal angiogenesis."EMBO J. 25:628-641(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity."J. Biol. Chem. 281:28185-28192(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity."Structure 14:321-330(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the second FN3 domain from human ephrin type-B receptor 4."Submitted (JUL-2007) to the PDB data bank
  17. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]