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Ras Homolog Gene Family, Member A (RHOA)

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ARH12; ARHA; RHO12; RHOH12; Rho cDNA clone 12

Ras Homolog Gene Family, Member A (RHOA)
CCC E320
HGNC 667
MGI 1096342
PubMed 24584070
RGD 619921
UniProt P61586
Wiki RHOA
RhoA is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. It acts upon two known effector proteins: ROCK1 and DIAPH1.
RhoA is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division.RhoA activates ROCK (RhoA kinase) which stimulates LIM kinase, which then stimulates Cofilin, which effectively re-organises the Actin cytoskeleton of the cell. In the case of neurons, activation of this pathway results in growth cone collapse, therefore inhibits the growth and repair of neural pathways and axons. Inhibition of this pathway by its various components usually results in some level of improved remyelination.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE320Hu01 Recombinant Ras Homolog Gene Family, Member A (RHOA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE320Hu21 Monoclonal Antibody to Ras Homolog Gene Family, Member A (RHOA) WB; IHC; ICC; IP.
PAE320Hu01 Polyclonal Antibody to Ras Homolog Gene Family, Member A (RHOA) WB; IHC; ICC; IP.
Assay Kits SEE320Hu ELISA Kit for Ras Homolog Gene Family, Member A (RHOA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member A (RHOA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member A (RHOA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member A (RHOA) Polyclonal Antibody Customized Service Offer
Assay Kits SEE320Mu ELISA Kit for Ras Homolog Gene Family, Member A (RHOA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member A (RHOA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member A (RHOA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member A (RHOA) Polyclonal Antibody Customized Service Offer
Assay Kits SEE320Ra ELISA Kit for Ras Homolog Gene Family, Member A (RHOA) Enzyme-linked immunosorbent assay for Antigen Detection.
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  34. "ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells."Proc. Natl. Acad. Sci. U.S.A. 107:18517-18522(2010) [PubMed] [Europe PMC] [Abstract]
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  42. "An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism."J. Biol. Chem. 275:18311-18317(2000) [PubMed] [Europe PMC] [Abstract]
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