Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)

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SLC20A2; Glvr-2; MLVAR; PIT-2; Sodium-dependent phosphate transporter 2; Phosphate transporter 2; Solute Carrier Family 20 Member 1,Phosphate Transporter

Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)
The host range of retroviruses is determined primarily by the presence of specific receptors on target cells which are recognized by the retroviral envelope glycoprotein. Kaelbling et al. (1991) described a receptor for the gibbon ape leukemia retrovirus. In an effort to isolate related human genes to determine if these function as receptors for any other retroviruses, van Zeijl et al. screened a human cDNA library at low stringency using GLVR1 as a probe. A single GLVR1-related cDNA (designated GLVR2) was isolated and found to have 62% identity to GLVR1 and its amino acid sequence. Expression of GLVR2 in CHO-K1 cells, which are resistant to infection by amphotropic virus because of the absence of a receptor, rendered the cells sensitive to infection by the virus. Thus, GLVR2 is a receptor for amphotropic virus.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)CLIA Kit Customized Service Offer
n/aELISA Kit for Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)CLIA Kit Customized Service Offer
n/aELISA Kit for Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)CLIA Kit Customized Service Offer
n/aELISA Kit for Gibbon Ape Leukemia Virus Receptor 2 (GLVR2)ELISA Kit Customized Service Offer
  1. "A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family."Proc. Natl. Acad. Sci. U.S.A. 91:1168-1172(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptor."J. Virol. 75:5584-5592(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The amphotropic murine leukemia virus receptor gene encodes a 71-kilodalton protein that is induced by phosphate depletion."J. Virol. 71:4564-4570(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of envelope determinants of feline leukemia virus subgroup B that permit infection and gene transfer to cells expressing human Pit1 or Pit2."J. Virol. 75:6841-6849(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function."J. Biol. Chem. 277:42741-42747(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2."FEBS J. 272:3060-3074(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2."Am. J. Physiol. 291:C1377-C1387(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis." Nat. Genet. 44:254-256(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Reporting a new mutation at the SLC20A2 gene in familial idiopathic basal ganglia calcification."Eur. J. Neurol. 20:E43-43(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Novel SLC20A2 mutations identified in southern Chinese patients with idiopathic basal ganglia calcification."Gene 529:159-162(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcification." Neurogenetics 14:11-22(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Primary familial brain calcification: Genetic analysis and clinical spectrum."Mov. Disord. 29:1691-1695(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Evaluation of SLC20A2 mutations that cause idiopathic basal ganglia calcification in Japan."Neurology 82:705-712(2014) [PubMed] [Europe PMC] [Abstract]