Organic Cation/Ergothioneine Transporter (OCTN1)

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SLC22A4; ETT; UT2H; Solute Carrier Family 22 Member 4; ET transporter

Organic Cation/Ergothioneine Transporter (OCTN1)
The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. The first functional designation of this protein was OCTN1 but efficiency of transport for organic cations is very low.The transport efficiency for carnitine is also negligible. Instead, the protein is responsible for the cotransport of sodium ions and ergothioneine, which is an antioxidant, into cells. Thus, a more appropriate functional designation is ETT ("ergothioneine transporter").Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE444Hu01 Recombinant Organic Cation/Ergothioneine Transporter (OCTN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE444Hu01 Polyclonal Antibody to Organic Cation/Ergothioneine Transporter (OCTN1) WB; IHC; ICC; IP.
MAE444Hu21 Monoclonal Antibody to Organic Cation/Ergothioneine Transporter (OCTN1) WB; IHC; ICC; IP.
Assay Kits SEE444Hu ELISA Kit for Organic Cation/Ergothioneine Transporter (OCTN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Organic Cation/Ergothioneine Transporter (OCTN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Cation/Ergothioneine Transporter (OCTN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Cation/Ergothioneine Transporter (OCTN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Cation/Ergothioneine Transporter (OCTN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Cation/Ergothioneine Transporter (OCTN1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1."FEBS Lett. 419:107-111(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Discovery of the ergothioneine transporter."Proc. Natl. Acad. Sci. U.S.A. 102:5256-5261(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations."J. Pharmacol. Exp. Ther. 289:768-773(1999) [PubMed] [Europe PMC] [Abstract]
  6. "An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis."Nat. Genet. 35:341-348(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population."J. Hum. Genet. 47:576-584(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population."J. Pharm. Sci. 93:2920-2926(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Functional variants of OCTN cation transporter genes are associated with Crohn disease."Nat. Genet. 36:471-475(2004) [PubMed] [Europe PMC] [Abstract]