Downregulated In Adenoma (DRA)

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SLC26A3; CLD; Solute Carrier Family 26 Member 3; Congenital Chloride Diarrhea; Chloride anion exchanger

Downregulated In Adenoma (DRA)
SLC26A3 is a transmembrane glycoprotein that functions as a sulfate transporter. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. Mutations in this gene have been associated with congenital chloride diarrhoea , a treatable disease.Its expression, which appeared to be limited to the mucosa of normal colon, was significantly decreased in adenomas and adenocarcinomas of the colon and was downregulated early in tumorigenesis.All exon/intron boundaries conformed to the GT/AG rule. Genomic sequencing of a BAC clone revealed the presence of another, highly homologous gene 3-prime of the CLD gene, with a similar genomic structure, identified as the Pendred syndrome gene (SLC26A4).

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Downregulated In Adenoma (DRA)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Downregulated In Adenoma (DRA)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Downregulated In Adenoma (DRA)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Downregulated In Adenoma (DRA)CLIA Kit Customized Service Offer
n/aELISA Kit for Downregulated In Adenoma (DRA)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Downregulated In Adenoma (DRA)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Downregulated In Adenoma (DRA)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Downregulated In Adenoma (DRA)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Downregulated In Adenoma (DRA)CLIA Kit Customized Service Offer
n/aELISA Kit for Downregulated In Adenoma (DRA)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Downregulated In Adenoma (DRA)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Downregulated In Adenoma (DRA)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Downregulated In Adenoma (DRA)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Downregulated In Adenoma (DRA)CLIA Kit Customized Service Offer
n/aELISA Kit for Downregulated In Adenoma (DRA)ELISA Kit Customized Service Offer
  1. "Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas."Proc. Natl. Acad. Sci. U.S.A. 90:4166-4170(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Similarities between a soybean nodulin, Neurospora crassa sulphate permease II and a putative human tumour suppressor."Trends Biochem. Sci. 19:19-19(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3-exchanger DRA in rabbit small intestinal mucosa."Biochemistry 44:4477-4487(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Role of N-glycosylation in cell surface expression and protection against proteolysis of the intestinal anion exchanger SLC26A3."Am. J. Physiol. 302:C781-C795(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea."Nat. Genet. 14:316-319(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Genetic background of congenital chloride diarrhea in high-incidence populations: Finland, Poland, and Saudi Arabia and Kuwait."Am. J. Hum. Genet. 63:760-768(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Clustering of private mutations in the congenital chloride diarrhea/down-regulated in adenoma gene."Hum. Mutat. 11:321-327(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of seven novel mutations including the first two genomic rearrangements in SLC26A3 mutated in congenital chloride diarrhea."Hum. Mutat. 18:233-242(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Genetic diagnosis by whole exome capture and massively parallel DNA sequencing."Proc. Natl. Acad. Sci. U.S.A. 106:19096-19101(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Update on SLC26A3 mutations in congenital chloride diarrhea."Hum. Mutat. 32:715-722(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Compound heterozygous mutations in the SLC26A3 gene in 2 Spanish siblings with congenital chloride diarrhea."J. Pediatr. Gastroenterol. Nutr. 52:106-110(2011) [PubMed] [Europe PMC] [Abstract]