Proton Coupled Folate Transporter (PCFT)

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SLC46A1; PCFT; HCP1; Solute Carrier Family 46 Member 1; Heme Carrier Protein 1

Proton Coupled Folate Transporter (PCFT)
SLC46A1 encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a transmembrane heme transporter in duodenal enterocytes and, potentially, in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene cause the autosomal recessive HFM disease. HFM is characterized by folate deficiency due to reduced intestinal folate absorption and subsequent anemia, hypoimmunoglobulinemia, and recurrent infections.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Proton Coupled Folate Transporter (PCFT)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Proton Coupled Folate Transporter (PCFT)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Proton Coupled Folate Transporter (PCFT)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Proton Coupled Folate Transporter (PCFT)CLIA Kit Customized Service Offer
n/aELISA Kit for Proton Coupled Folate Transporter (PCFT)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Proton Coupled Folate Transporter (PCFT)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Proton Coupled Folate Transporter (PCFT)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Proton Coupled Folate Transporter (PCFT)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Proton Coupled Folate Transporter (PCFT)CLIA Kit Customized Service Offer
n/aELISA Kit for Proton Coupled Folate Transporter (PCFT)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Proton Coupled Folate Transporter (PCFT)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Proton Coupled Folate Transporter (PCFT)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Proton Coupled Folate Transporter (PCFT)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Proton Coupled Folate Transporter (PCFT)CLIA Kit Customized Service Offer
n/aELISA Kit for Proton Coupled Folate Transporter (PCFT)ELISA Kit Customized Service Offer
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  5. "Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption."Cell 127:917-928(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Haem carrier protein 1 (HCP1): expression and functional studies in cultured cells."FEBS Lett. 580:6865-6870(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption."Blood 110:1147-1152(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium."Exp. Cell Res. 313:1251-1259(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter."J. Pharmacol. Exp. Ther. 322:469-476(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane."FEBS J. 280:2900-2915(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter."J. Biol. Chem. 289:25287-25295(2014) [PubMed] [Europe PMC] [Abstract]
  17. "A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function."Blood 112:2055-2061(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption."Am. J. Physiol. 299:C1153-C1161(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption."Blood 116:5162-5169(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption."Mol. Genet. Metab. 103:33-37(2011) [PubMed] [Europe PMC] [Abstract]