Membrane Associated Transporter (MATP)

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SLC45A2; AIM1; 1A1; Solute Carrier Family 45 Member 2; Melanoma antigen AIM1

Membrane Associated Transporter (MATP)
SLC45A2 is a transporter protein that mediates melanin synthesis. SLC45A2 is also a melanocyte differentiation antigen that is expressed in a high percentage of melanoma cell lines. A similar sequence gene in medaka, 'B,' encodes a transporter that mediates melanin synthesis. Mutations in this gene are a cause of oculocutaneous albinism type 4. Alternative splicing results in multiple transcript variants encoding different isoforms.In melanocytic cell types, the SLC45A2 gene is regulated by microphthalmia-associated transcription factor.AIM1 gene was expressed in 3 melanoma cell lines, but not in a fibroblast cell line, and not at significant levels in any of 15 normal tissues. The human AIM1 gene encodes a protein of 530 amino acids. Northern blot analysis detected 2 transcripts, one of 1.7 kb and the other of 2.8 kb.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Membrane Associated Transporter (MATP)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Membrane Associated Transporter (MATP)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Membrane Associated Transporter (MATP)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Membrane Associated Transporter (MATP)CLIA Kit Customized Service Offer
n/aELISA Kit for Membrane Associated Transporter (MATP)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Membrane Associated Transporter (MATP)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Membrane Associated Transporter (MATP)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Membrane Associated Transporter (MATP)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Membrane Associated Transporter (MATP)CLIA Kit Customized Service Offer
n/aELISA Kit for Membrane Associated Transporter (MATP)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Membrane Associated Transporter (MATP)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Membrane Associated Transporter (MATP)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Membrane Associated Transporter (MATP)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Membrane Associated Transporter (MATP)CLIA Kit Customized Service Offer
n/aELISA Kit for Membrane Associated Transporter (MATP)ELISA Kit Customized Service Offer
  1. "Use of an in vitro immunoselected tumor line to identify shared melanoma antigens recognized by HLA-A*0201-restricted T cells."Cancer Res. 61:1089-1094(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in the human orthologue of the mouse underwhite gene (uw) underlie a new form of oculocutaneous albinism, OCA4."Am. J. Hum. Genet. 69:981-988(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Oculocutaneous albinism type 4 is one of the most common types of albinism in Japan."Am. J. Hum. Genet. 74:466-471(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in the MATP gene in five German patients affected by oculocutaneous albinism type 4."Hum. Mutat. 23:106-110(2004) [PubMed] [Europe PMC] [Abstract]
  8. "MATP polymorphisms in Germans and Japanese: the L374F mutation as a population marker for Caucasoids."Int. J. Legal Med. 118:364-366(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A Korean case of oculocutaneous albinism type IV caused by a D157N mutation in the MATP gene."Br. J. Dermatol. 152:174-175(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation variation."Hum. Mutat. 25:278-284(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Distribution of the F374 allele of the SLC45A2 (MATP) gene and founder-haplotype analysis."Ann. Hum. Genet. 70:802-811(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A genomewide association study of skin pigmentation in a South Asian population."Am. J. Hum. Genet. 81:1119-1132(2007) [PubMed] [Europe PMC] [Abstract]
  13. "SLC45A2 variations in Indian oculocutaneous albinism patients."Mol. Vis. 13:1406-1411(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Variants of the MATP/SLC45A2 gene are protective for melanoma in the French population." Hum. Mutat. 29:1154-1160(2008) [PubMed] [Europe PMC] [Abstract]
  15. "SLC45A2: a novel malignant melanoma-associated gene."Hum. Mutat. 29:1161-1167(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A comprehensive analysis reveals mutational spectra and common alleles in Chinese patients with oculocutaneous albinism."J. Invest. Dermatol. 130:716-724(2010) [PubMed] [Europe PMC] [Abstract]
  17. "DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics."Hum. Mutat. 34:827-835(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Mutational spectrum of the TYR and SLC45A2 genes in Pakistani families with oculocutaneous albinism, and potential founder effect of missense substitution (p.Arg77Gln) of tyrosinase."Clin. Exp. Dermatol. 0:0-0(2015) [PubMed] [Europe PMC] [Abstract]