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Choline Transporter Like Protein 2 (CTL2)

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SLC44A2; Solute Carrier Family 44 Member 2

Choline Transporter Like Protein 2 (CTL2)
CCC E514
HGNC 17292
MGI 1915932
PubMed 21986210
UniProt Q8IWA5
Wiki SLC44A2
Choline, a major constituent of cell membranes, participates in the synthesis of acetylcholine in cholinergic neurons. It is taken up with high affinity at cholinergic nerve terminals in a sodium-dependent manner. O'Regan et al. (2000) cloned CTL1, a suppressor for a yeast choline transport mutation, from a Torpedo electric lobe yeast expression library by functional complementation. By EST database searching and PCR on a sarcoma cell line, they obtained cDNAs encoding human CTL1, CTL2, and CTL4 .
The predicted 706-amino acid CTL2 protein is 43% and 67% homologous to human CTL1 and CTL4, respectively. The CTL proteins contain 10 transmembrane domains and 11 highly conserved cysteines, and they lack signal peptides.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE514Hu01 Recombinant Choline Transporter Like Protein 2 (CTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Choline Transporter Like Protein 2 (CTL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Choline Transporter Like Protein 2 (CTL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Choline Transporter Like Protein 2 (CTL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Choline Transporter Like Protein 2 (CTL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE514Mu01 Recombinant Choline Transporter Like Protein 2 (CTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Choline Transporter Like Protein 2 (CTL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Choline Transporter Like Protein 2 (CTL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Choline Transporter Like Protein 2 (CTL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Choline Transporter Like Protein 2 (CTL2) ELISA Kit Customized Service Offer
  1. "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins."Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss."J. Neurosci. 24:1772-1779(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Cochlin isoforms and their interaction with CTL2 (SLC44A2) in the inner ear."J. Assoc. Res. Otolaryngol. 8:435-446(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Isoforms, expression, glycosylation, and tissue distribution of CTL2/SLC44A2."Protein J. 29:417-426(2010) [PubMed] [Europe PMC] [Abstract]