Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1)

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LST1; OATPC; OATP1B1; OATP2; SLC21A6; Solute Carrier 21 Member 6; Sodium-independent organic anion-transporting polypeptide 2; Liver-specific organic anion transporter 1

Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1)
SLCO1B1is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. The SLC21A6 gene encodes a deduced 691-amino acid protein containing 12 transmembrane domains, 7 putative N-glycosylation sites in the extracellular loops, and 2 potential phosphorylation sites. Northern blot analysis detected major 3.0- and minor 4.8-kb SLC21A6 transcripts exclusively in liver, in contrast to the more widely expressed SLC21A3.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1)CLIA Kit Customized Service Offer
n/aELISA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1)ELISA Kit Customized Service Offer
  1. "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1."J. Biol. Chem. 274:17159-17163(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters."J. Biol. Chem. 274:37161-37168(1999) [PubMed] [Europe PMC] [Abstract]
  3. "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane."Am. J. Physiol. 278:G156-G164(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."J. Biol. Chem. 275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver."J. Clin. Invest. 122:519-528(2012) [PubMed] [Europe PMC] [Abstract]
  8. "N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1."PLoS ONE 7:E52563-E52563(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans."J. Biol. Chem. 276:35669-35675(2001) [PubMed] [Europe PMC] [Abstract]
  11. "A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter."J. Biol. Chem. 277:43058-43063(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis."J. Pharmacol. Exp. Ther. 302:804-813(2002) [PubMed] [Europe PMC] [Abstract]