Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)

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LST-3TM13; LST3; OATP1B3; OATP8; SLC21A8; Liver-specific organic anion transporter 2; solute carrier family 21 Member 8; Organic Anion Transporting Polypeptide 8

Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)
Based on sequence homology to human organic anion transporter-2 (OATP2, or SLC21A6), Konig et al. (2000) cloned a new member of the SLC21A superfamily, which they termed OATP8 (SLC21A8). The deduced 702-amino acid OATP8 protein shares 80% sequence identity with OATP2, a hepatic basolateral uptake transporter. Northern blot analysis revealed a liver-specific expression pattern similar to that of OATP2. An antibody raised against the C terminus localized OATP8 to the basolateral membrane of human hepatocytes and the recombinant glycoprotein, expressed in MDCKII cells, to the lateral membrane.OATP8 is also an uptake transporter of organic anions including sulfobromophthalein and 17-beta-glucuronosyl estradiol. They also found that OATP8 did not transport several bile salts that are transported by OATP2.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)CLIA Kit Customized Service Offer
n/aELISA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)CLIA Kit Customized Service Offer
n/aELISA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)CLIA Kit Customized Service Offer
n/aELISA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B3 (SLCO1B3)ELISA Kit Customized Service Offer
  1. "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."J. Biol. Chem. 275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
  2. "LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers." Gastroenterology 120:1689-1699(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver."J. Clin. Invest. 122:519-528(2012) [PubMed] [Europe PMC] [Abstract]
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  6. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]