Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)

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p15; INK4B; MTS2; TP15; Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2

Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)
Cyclin-dependent kinase 4 inhibitor B lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors.
This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases by cyclin D, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)CLIA Kit Customized Service Offer
n/aELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPE627Mu01Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAE627Mu01Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
Assay Kitsn/aCLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)CLIA Kit Customized Service Offer
n/aELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)CLIA Kit Customized Service Offer
n/aELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)ELISA Kit Customized Service Offer
  1. "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function."Genes Dev. 8:2939-2952(1994) [PubMed] [Europe PMC] [Abstract]
  2. "p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest."Nature 371:257-261(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor."Cancer Res. 57:2966-2973(1997) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A cell cycle regulator potentially involved in genesis of many tumor types."Science 264:436-440(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data."Protein Sci. 9:1120-1128(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer."Cancer Res. 55:1448-1451(1995) [PubMed] [Europe PMC] [Abstract]