Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)

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NMDAR2B; NR2B; hNR3; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)
The N-methyl-D-aspartate (NMDA) receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. Functional NMDA receptors appear to be composed (minimally) of an invariant subunit (NMDAR1) and 1 of several variable subunits . Each of the variable subunits exhibits a distinct distribution in the adult brain. For example, postnatally, NMDA receptors containing the NMDAR2B subunit are primarily localized to the hippocampus and forebrain. The sequence of the predicted 1,484-amino acid human protein is 98% and 96% identical to the sequences of the rat and mouse Nmdar2b proteins, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPE807Hu01Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)SDS-PAGE; WB; ELISA; IP.
AntibodiesMAE807Hu21Monoclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)WB, ICC, IHC-P, IHC-F, ELISA
PAE807Hu01Polyclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEE807HuELISA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)CLIA Kit Customized Service Offer
n/aELISA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)CLIA Kit Customized Service Offer
n/aELISA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)ELISA Kit Customized Service Offer
  1. "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein."Biochim. Biophys. Acta 1260:105-108(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors."J. Pharmacol. Exp. Ther. 278:808-816(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12."Genomics 22:216-218(1994) [PubMed] [Europe PMC] [Abstract]
  5. "mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit."Neurosci. Lett. 239:49-53(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase."J. Biol. Chem. 275:21477-21485(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes." Nat. Genet. 42:1021-1026(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]
  9. "GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy."Ann. Neurol. 75:147-154(2014) [PubMed] [Europe PMC] [Abstract]