≡

Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1)

[Edit]

ATQ1; PDE; EPD; Antiquitin; Alpha-Aminoadipic Semialdehyde Dehydrogenase; Delta1-Piperideine-6-Carboxylate Dehydrogenease; P6c Dehydrogenase

Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1)
CCC E837
HGNC 877
MGI 108186
PubMed 20207735
RGD 1308614
UniProt P49419
Wiki ALDH7A1
Antiquitin is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein.The ALDH7A1 gene encodes a 510-amino acid protein.
Antiquitin functions as an aldehyde dehydrogenase in the pipecolic acid pathway of lysine catabolism. Mutations in this gene cause pyridoxine-dependent epilepsy, which involves a combination of various seizure types and is responsive to immediate administration of pyridoxine hydrochloride.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE837Hu01 Recombinant Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE837Hu01 Polyclonal Antibody to Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) WB; IHC; ICC; IP.
LAE837Hu71 Biotin-Linked Polyclonal Antibody to Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) WB; IHC; ICC.
MAE837Hu21 Monoclonal Antibody to Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE837Mu01 Recombinant Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE837Mu01 Polyclonal Antibody to Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) WB; IHC; ICC; IP.
LAE837Mu71 Biotin-Linked Polyclonal Antibody to Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) WB; IHC; ICC.
Assay Kits SEE837Mu ELISA Kit for Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE837Ra01 Recombinant Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE837Ra01 Polyclonal Antibody to Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) WB; IHC; ICC; IP.
LAE837Ra71 Biotin-Linked Polyclonal Antibody to Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) ELISA Kit Customized Service Offer
  1. "Homology between a human protein and a protein of the green garden pea."Genomics 21:371-378(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1)."Genomics 46:191-199(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress."J. Biol. Chem. 285:18452-18463(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in antiquitin in individuals with pyridoxine-dependent seizures."Nat. Med. 12:307-309(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Biochemical and molecular characterization of 18 patients with pyridoxine-dependent epilepsy and mutations of the antiquitin (ALDH7A1) gene."Hum. Mutat. 28:19-26(2007) [PubMed] [Europe PMC] [Abstract]