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Arkadia (ARK)

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RNF111; Ring Finger Protein 111; E3 ubiquitin-protein ligase Arkadia

Arkadia (ARK)
CCC E940
HGNC 17384
MGI 1934919
PubMed 21795712
RGD 1310097
UniProt Q6ZNA4
Wiki RNF111
The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.The human Arkadia amino acid sequence is 90%, 83%, and 73% identical to that of mouse, chick, and Xenopus, respectively. The Arkadia protein possesses a RING-H2 finger motif at its carboxy-terminal end. It also has 2 putative nuclear localization signals and low-complexity amino acid repeats. Arkadia is essential for HNF3B expression in the anterior primitive streak. Analysis with chimeras, however, shows that Arkadia functions within extraembryonic tissues, revealing that these are required to induce the node.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE940Hu01 Recombinant Arkadia (ARK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Arkadia (ARK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arkadia (ARK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arkadia (ARK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arkadia (ARK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arkadia (ARK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arkadia (ARK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arkadia (ARK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arkadia (ARK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arkadia (ARK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arkadia (ARK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arkadia (ARK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arkadia (ARK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arkadia (ARK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arkadia (ARK) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7."EMBO J. 22:6458-6470(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."EMBO J. 25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation."Mol. Cell. Biol. 27:6068-6083(2007) [PubMed] [Europe PMC] [Abstract]
  8. "PolySUMO-binding proteins identified through a string search."J. Biol. Chem. 287:42071-42083(2012) [PubMed] [Europe PMC] [Abstract]
  9. "NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase."Proteins 80:1484-1489(2012) [PubMed] [Europe PMC] [Abstract]