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Eukaryotic Translation Initiation Factor 3G (EIF3G)

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EIF3S4; EIF3-P42; eIF3-delta; eIF3-p44; eIF3g; Eukaryotic translation initiation factor 3 subunit 4; eIF-3-delta; eIF-3 RNA-binding subunit

Eukaryotic Translation Initiation Factor 3G (EIF3G)
CCC F003
HGNC 3274
MGI 1858258
PubMed 17094969
RGD 1307191
UniProt O75821
Wiki EIF3G
Sequence analysis indicated that human p44 shares 97% protein sequence identity with the predicted mouse p44 homolog and 33% identity with the S. cerevisiae eIF3-p33 subunit. p44 binds RNA, as do eIF3 subunits p170 and p66. On Far Western blots, the p44 protein interacted strong and specifically with p170, and weakly with p116/p110, p66, p40 , and itself. Northern blot analysis revealed that p44 is expressed as an approximately 1.4-kb mRNA in HeLa cells.When expressed in mammalian cells, epitope-tagged p42 was incorporated into endogenous eIF3. The authors found that a major fraction of endogenous eIF5 was associated with eIF3, leading them to suggest that a specific interaction between these 2 initiation factors may play an important role in the function of eIF5 during translation initiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3G (EIF3G) Monoclonal Antibody Customized Service Offer
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Assay Kits SEF003Hu ELISA Kit for Eukaryotic Translation Initiation Factor 3G (EIF3G) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3G (EIF3G) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3G (EIF3G) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3G (EIF3G) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3G (EIF3G) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3G (EIF3G) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3G (EIF3G) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3G (EIF3G) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3G (EIF3G) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3G (EIF3G) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3G (EIF3G) ELISA Kit Customized Service Offer
  1. "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3."J. Biol. Chem. 273:31901-31908(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells."Nucleic Acids Res. 27:1331-1337(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3."Eur. J. Biochem. 270:4133-4139(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro."J. Biol. Chem. 279:8946-8956(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association."RNA 11:470-486(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g)."FEBS Lett. 580:6375-6383(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit."J. Biol. Chem. 281:22917-22932(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Reconstitution reveals the functional core of mammalian eIF3."EMBO J. 26:3373-3383(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry."Mol. Cell. Proteomics 6:1135-1146(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3."Proc. Natl. Acad. Sci. U.S.A. 105:18139-18144(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Structural roles for human translation factor eIF3 in initiation of protein synthesis."Science 310:1513-1515(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of RNA binding domain in eukaryotic translation initiation factor 3 subunit 4."Submitted (NOV-2005) to the PDB data bank