Mediator Complex Subunit 12 (MED12)

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OPA1; CAGH45; HOPA; TNRC11; TRAP230; Trinucleotide Repeat Containing 11; Activator-recruited cofactor 240 kDa; Thyroid hormone receptor-associated 230 kDa; OPA-containing

Mediator Complex Subunit 12 (MED12)
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C.
The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Mediator Complex Subunit 12 (MED12)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Mediator Complex Subunit 12 (MED12)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Mediator Complex Subunit 12 (MED12)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Mediator Complex Subunit 12 (MED12)CLIA Kit Customized Service Offer
n/aELISA Kit for Mediator Complex Subunit 12 (MED12)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Mediator Complex Subunit 12 (MED12)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Mediator Complex Subunit 12 (MED12)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Mediator Complex Subunit 12 (MED12)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Mediator Complex Subunit 12 (MED12)CLIA Kit Customized Service Offer
n/aELISA Kit for Mediator Complex Subunit 12 (MED12)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Mediator Complex Subunit 12 (MED12)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Mediator Complex Subunit 12 (MED12)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Mediator Complex Subunit 12 (MED12)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Mediator Complex Subunit 12 (MED12)CLIA Kit Customized Service Offer
n/aELISA Kit for Mediator Complex Subunit 12 (MED12)ELISA Kit Customized Service Offer
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  10. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
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  13. "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Mediator modulates Gli3-dependent Sonic hedgehog signaling."Mol. Cell. Biol. 26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
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  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene."J. Med. Genet. 44:472-477(2007) [PubMed] [Europe PMC] [Abstract]
  22. "A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome."Nat. Genet. 39:451-453(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Mutations in MED12 cause X-linked Ohdo syndrome."Am. J. Hum. Genet. 92:401-406(2013) [PubMed] [Europe PMC] [Abstract]