Ubiquitin Specific Peptidase 9Y (USP9Y)

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SP3; AZF; AZFA; DFFRY; Fat Facets-Like; Ubiquitin Specific Protease 9Y; Deubiquitinating enzyme FAF-Y; Ubiquitin thioesterase FAF-Y; ubiquitin carboxyl-terminal hydrolase FAF-Y

Ubiquitin Specific Peptidase 9Y (USP9Y)
Ubiquitin specific peptidase 9, Y-linked is required for sperm production. This enzyme is a member of the peptidase C19 family and is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.
The USP9Y gene is found on the azoospermia factor (AZF) region on the Y chromosome. Men who have impaired or no sperm production often have a deletion in the AZF region, especially in the USP9Y gene, and it was thought that USP9Y was necessary for sperm production. However, a man and his father with a USP9Y deletion who could produce sperm were recently reported. The corresponding gene is present but inactive in chimpanzees and bonobos.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ubiquitin Specific Peptidase 9Y (USP9Y)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ubiquitin Specific Peptidase 9Y (USP9Y)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ubiquitin Specific Peptidase 9Y (USP9Y)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ubiquitin Specific Peptidase 9Y (USP9Y)CLIA Kit Customized Service Offer
n/aELISA Kit for Ubiquitin Specific Peptidase 9Y (USP9Y)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ubiquitin Specific Peptidase 9Y (USP9Y)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ubiquitin Specific Peptidase 9Y (USP9Y)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ubiquitin Specific Peptidase 9Y (USP9Y)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ubiquitin Specific Peptidase 9Y (USP9Y)CLIA Kit Customized Service Offer
n/aELISA Kit for Ubiquitin Specific Peptidase 9Y (USP9Y)ELISA Kit Customized Service Offer
  1. "The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2."Hum. Mol. Genet. 5:1695-1701(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Functional coherence of the human Y chromosome."Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene."Hum. Mol. Genet. 7:97-107(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract]
  5. "An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y."Nat. Genet. 23:429-432(1999) [PubMed] [Europe PMC] [Abstract]
  6. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Spermatogenesis in a man with complete deletion of USP9Y."N. Engl. J. Med. 360:881-885(2009) [PubMed] [Europe PMC] [Abstract]