Erythrocyte Membrane Protein Band 4.2 (EPB42)

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PA; Erythrocyte Surface Protein Band 4.2

Erythrocyte Membrane Protein Band 4.2 (EPB42)
Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia.
The deduced 691-amino acid band 4.2 protein has homology with 2 closely related calcium-dependent crosslinking proteins, guinea pig liver transglutaminase and the alpha subunit of human coagulation factor XIII (F13A1). Within the 5 contiguous consensus residues of the transglutaminase active site, band 4.2 has an amino acid substitution which leads to loss of transglutaminase activity.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPF170Hu01Recombinant Erythrocyte Membrane Protein Band 4.2 (EPB42)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAF170Hu01Polyclonal Antibody to Erythrocyte Membrane Protein Band 4.2 (EPB42)WB, ICC, IHC-P, IHC-F, ELISA
MAF170Hu21Monoclonal Antibody to Erythrocyte Membrane Protein Band 4.2 (EPB42)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEF170HuELISA Kit for Erythrocyte Membrane Protein Band 4.2 (EPB42)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Erythrocyte Membrane Protein Band 4.2 (EPB42)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Erythrocyte Membrane Protein Band 4.2 (EPB42)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Erythrocyte Membrane Protein Band 4.2 (EPB42)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Erythrocyte Membrane Protein Band 4.2 (EPB42)CLIA Kit Customized Service Offer
n/aELISA Kit for Erythrocyte Membrane Protein Band 4.2 (EPB42)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Erythrocyte Membrane Protein Band 4.2 (EPB42)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Erythrocyte Membrane Protein Band 4.2 (EPB42)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Erythrocyte Membrane Protein Band 4.2 (EPB42)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Erythrocyte Membrane Protein Band 4.2 (EPB42)CLIA Kit Customized Service Offer
n/aELISA Kit for Erythrocyte Membrane Protein Band 4.2 (EPB42)ELISA Kit Customized Service Offer
  1. "Organization of the gene for human erythrocyte membrane protein 4.2: structural similarities with the gene for the a subunit of factor XIII."Proc. Natl. Acad. Sci. U.S.A. 88:4840-4844(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Complete amino acid sequence and homologies of human erythrocyte membrane protein band 4.2."Proc. Natl. Acad. Sci. U.S.A. 87:613-617(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of human protein 4.2: a major component of the erythrocyte membrane."Proc. Natl. Acad. Sci. U.S.A. 87:955-959(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human erythrocyte protein 4.2, a high copy number membrane protein, is N-myristylated."J. Biol. Chem. 267:5680-5685(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Structural domain mapping and phosphorylation of human erythrocyte pallidin (band 4.2)."Biochim. Biophys. Acta 1148:19-29(1993) [PubMed] [Europe PMC] [Abstract]
  8. "An alanine-to-threonine substitution in protein 4.2 cDNA is associated with a Japanese form of hereditary hemolytic anemia (protein 4.2 Nippon)."Blood 79:1846-1854(1992) [PubMed] [Europe PMC] [Abstract]
  9. "A novel mutation in the erythrocyte protein 4.2 gene of Japanese patients with hereditary spherocytosis (protein 4.2 Fukuoka)."Br. J. Haematol. 88:527-533(1994) [PubMed] [Europe PMC] [Abstract]
  10. "A point mutation in the protein 4.2 gene (allele 4.2 Tozeur) associated with hereditary haemolytic anaemia."Br. J. Haematol. 89:762-770(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Band 4.2 Shiga: 317 CGC-->TGC in compound heterozygotes with 142 GCT-->ACT results in band 4.2 deficiency and microspherocytosis."Br. J. Haematol. 91:333-340(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Band 4.2 Komatsu: 523 GAT-->TAT (175 Asp-->Tyr) in exon 4 of the band 4.2 gene associated with total deficiency of band 4.2, hemolytic anemia with ovalostomatocytosis and marked disruption of the cytoskeletal network."Int. J. Hematol. 61:165-178(1995) [PubMed] [Europe PMC] [Abstract]
  13. "4.2 Nippon mutation in a non-Japanese patient with hereditary spherocytosis."Haematologica 84:660-662(1999) [PubMed] [Europe PMC] [Abstract]