Aminolevulinate Delta Synthase 1 (ALAS1)

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ALAS3; ALAS; ALASH; 5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; 5-aminolevulinate synthase, nonspecific, mitochondrial

Aminolevulinate Delta Synthase 1 (ALAS1)
Delta-aminolevulinate synthase 1 is an aminolevulinic acid synthase. Delta-aminolevulinate synthase catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2.
ALAS1encodes a housekeeping form of ALAS inasmuch as it is expressed in all cell types, including erythroid cells, whereas ALAS2 encodes a red cell-specific form. ALAS1 and ALAS2 have only 59% identity in amino acid sequence; there was no homology in the amino-terminal region and about 73% homology after hepatic residue 197.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Aminolevulinate Delta Synthase 1 (ALAS1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Aminolevulinate Delta Synthase 1 (ALAS1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Aminolevulinate Delta Synthase 1 (ALAS1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Aminolevulinate Delta Synthase 1 (ALAS1)CLIA Kit Customized Service Offer
n/aELISA Kit for Aminolevulinate Delta Synthase 1 (ALAS1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Aminolevulinate Delta Synthase 1 (ALAS1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Aminolevulinate Delta Synthase 1 (ALAS1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Aminolevulinate Delta Synthase 1 (ALAS1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Aminolevulinate Delta Synthase 1 (ALAS1)CLIA Kit Customized Service Offer
n/aELISA Kit for Aminolevulinate Delta Synthase 1 (ALAS1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPF209Ra01Recombinant Aminolevulinate Delta Synthase 1 (ALAS1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAF209Ra01Polyclonal Antibody to Aminolevulinate Delta Synthase 1 (ALAS1)WB, ICC, IHC-P, IHC-F, ELISA
MAF209Ra21Monoclonal Antibody to Aminolevulinate Delta Synthase 1 (ALAS1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEF209RaELISA Kit for Aminolevulinate Delta Synthase 1 (ALAS1)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "Two different genes encode delta-aminolevulinate synthase in humans: nucleotide sequences of cDNAs for the housekeeping and erythroid genes."Nucleic Acids Res. 18:7187-7188(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence of human 5-aminolevulinate synthase cDNA."Nucleic Acids Res. 15:8563-8563(1987) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]