Cryptochrome 2 (CRY2)

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HCRY2; PHLL2; Photolyase-Like 2

Cryptochrome 2 (CRY2)

Cryptochrome-2 is a protein responsible for blue-light mediated cotyledon/leaf expansion. CRY2 overexpression in transgenic plants results in a large increase in blue light-stimulated cotyledon expansion. The plants will have many broad leaves and no flowers, rather than a few primary leaves with a flower emerging from them. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, sketal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle.It is also found in plants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cryptochrome 2 (CRY2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cryptochrome 2 (CRY2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cryptochrome 2 (CRY2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cryptochrome 2 (CRY2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cryptochrome 2 (CRY2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cryptochrome 2 (CRY2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cryptochrome 2 (CRY2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cryptochrome 2 (CRY2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cryptochrome 2 (CRY2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cryptochrome 2 (CRY2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cryptochrome 2 (CRY2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cryptochrome 2 (CRY2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cryptochrome 2 (CRY2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cryptochrome 2 (CRY2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cryptochrome 2 (CRY2) ELISA Kit Customized Service Offer
  1. "Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins."Biochemistry 35:13871-13877(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of photolyase/blue-light receptor homologs in mouse and human cells."Nucleic Acids Res. 26:5086-5092(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Light-independent role of CRY1 and CRY2 in the mammalian circadian clock."Science 286:768-771(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein."EMBO J. 21:1301-1314(2002) [PubMed] [Europe PMC] [Abstract]
  9. "A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation."Biochem. Biophys. Res. Commun. 313:117-124(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5."Proc. Natl. Acad. Sci. U.S.A. 103:10467-10472(2006) [PubMed] [Europe PMC] [Abstract]
  11. "SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins."Science 316:900-904(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Metabolism and the circadian clock converge."Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular architecture of the mammalian circadian clock."Trends Cell Biol. 24:90-99(2014) [PubMed] [Europe PMC] [Abstract]