Lysophosphatidic Acid Receptor 6 (LPAR6)

[Edit]

P2Y5; P2RY5; Purinergic Receptor P2Y,G-Protein Coupled 5; Oleoyl-L-alpha-lysophosphatidic acid receptor; RB intron encoded G-protein coupled receptor

Lysophosphatidic Acid Receptor 6 (LPAR6)
Lysophosphatidic acid receptor 6 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA). The proteinbelongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.
It is the first receptor in humans known to play a role in hair growth. The fact that any receptor plays a specific role in hair growth was previously unknown to scientists and with this new knowledge a focus on finding more of these genes may be able to lead to therapies for many different types of hair loss

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Lysophosphatidic Acid Receptor 6 (LPAR6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Lysophosphatidic Acid Receptor 6 (LPAR6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Lysophosphatidic Acid Receptor 6 (LPAR6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Lysophosphatidic Acid Receptor 6 (LPAR6)CLIA Kit Customized Service Offer
n/aELISA Kit for Lysophosphatidic Acid Receptor 6 (LPAR6)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Lysophosphatidic Acid Receptor 6 (LPAR6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Lysophosphatidic Acid Receptor 6 (LPAR6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Lysophosphatidic Acid Receptor 6 (LPAR6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Lysophosphatidic Acid Receptor 6 (LPAR6)CLIA Kit Customized Service Offer
n/aELISA Kit for Lysophosphatidic Acid Receptor 6 (LPAR6)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Lysophosphatidic Acid Receptor 6 (LPAR6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Lysophosphatidic Acid Receptor 6 (LPAR6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Lysophosphatidic Acid Receptor 6 (LPAR6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Lysophosphatidic Acid Receptor 6 (LPAR6)CLIA Kit Customized Service Offer
n/aELISA Kit for Lysophosphatidic Acid Receptor 6 (LPAR6)ELISA Kit Customized Service Offer
  1. "Complete genomic sequence of the human retinoblastoma susceptibility gene."Genomics 17:535-543(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene."Genome Res. 6:858-861(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells."Biochim. Biophys. Acta 1492:127-138(2000) [PubMed] [Europe PMC] [Abstract]
  8. "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth."Nat. Genet. 40:329-334(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair."Nat. Genet. 40:335-339(2008) [PubMed] [Europe PMC] [Abstract]