Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)

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ZP3A; ZP3B; Zona pellucida sperm-binding protein 3; Sperm receptor; Zona pellucida protein C

Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)
During the process of fertilization, the initial interaction between male and female gametes is mediated by a sperm receptor, designated ZP3, which resides in the extracellular glycoprotein matrix surrounding the oocyte. The sperm receptor function of the ZP3 molecule plays a key role in the first step of the fertilization process. Following sperm-oocyte binding, ZP3 triggers the sperm acrosome reaction that releases the protein machinery enabling a spermatozoon to penetrate the zona pellucida. The distribution of these 3 patterns was significantly different between the Caucasian and Japanese populations, as indicated by ZP3-372 allele frequencies of 69 and 21%, respectively. Provided that ZP3-372 mRNA is translated in vivo, differences in the protein gene product might have an impact on human zona pellucida composition.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)CLIA Kit Customized Service Offer
n/aELISA Kit for Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)CLIA Kit Customized Service Offer
n/aELISA Kit for Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)CLIA Kit Customized Service Offer
n/aELISA Kit for Zona Pellucida Glycoprotein 3, Sperm Receptor (ZP3)ELISA Kit Customized Service Offer
  1. "Human homolog of the mouse sperm receptor."Proc. Natl. Acad. Sci. U.S.A. 87:6014-6018(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations."Genomics 14:1064-1070(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells."Biochemistry 43:12090-12104(2004) [PubMed] [Europe PMC] [Abstract]