Phosphodiesterase 6A, cGMP Specific (PDE6A)

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PDEA; PDE V-B1; Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Phosphodiesterase 6A, cGMP Specific (PDE6A)
PDE6A encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. the human PDEA gene consists of 22 exons spanning approximately 45 to 50 kb.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Phosphodiesterase 6A, cGMP Specific (PDE6A)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Phosphodiesterase 6A, cGMP Specific (PDE6A)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Phosphodiesterase 6A, cGMP Specific (PDE6A)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Phosphodiesterase 6A, cGMP Specific (PDE6A)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphodiesterase 6A, cGMP Specific (PDE6A)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Phosphodiesterase 6A, cGMP Specific (PDE6A)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Phosphodiesterase 6A, cGMP Specific (PDE6A)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Phosphodiesterase 6A, cGMP Specific (PDE6A)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Phosphodiesterase 6A, cGMP Specific (PDE6A)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphodiesterase 6A, cGMP Specific (PDE6A)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Phosphodiesterase 6A, cGMP Specific (PDE6A)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Phosphodiesterase 6A, cGMP Specific (PDE6A)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Phosphodiesterase 6A, cGMP Specific (PDE6A)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Phosphodiesterase 6A, cGMP Specific (PDE6A)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphodiesterase 6A, cGMP Specific (PDE6A)ELISA Kit Customized Service Offer
  1. "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene."Genomics 6:272-283(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase."Nat. Genet. 11:468-471(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Frequency of mutations in the gene encoding the alpha subunit of rod cGMP-phosphodiesterase in autosomal recessive retinitis pigmentosa."Invest. Ophthalmol. Vis. Sci. 40:1859-1865(1999) [PubMed] [Europe PMC] [Abstract]