Phosphatase And Actin Regulator 1 (PHACTR1)

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RPEL1; RPEL Repeat Containing 1

Phosphatase And Actin Regulator 1 (PHACTR1)
The PHACTR proteins share highest similarity in sequences surrounding the N- and C-terminal RPEL repeats and in the C-terminal actin- and PP1-binding domains. In situ hybridization of rat brain showed enrichment of Phactr1 in cerebral cortex, hippocampus, olfactory tubercle, nucleus accumbens, caudate-putamen, and piriform cortex.
Endogenous PP1 coprecipitated with ectopically expressed rat Phactr1 in human embryonic kidney cells. Phactr1 also coprecipitated with actin in rat brain lysates. Yeast 2-hybrid analysis of a series of Phactr1 C-terminal truncation mutants indicated that PP1 bound to Phactr1 near the C terminus, while actin bound in a region containing RPEL repeats 2 and 3.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Phosphatase And Actin Regulator 1 (PHACTR1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Phosphatase And Actin Regulator 1 (PHACTR1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Phosphatase And Actin Regulator 1 (PHACTR1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Phosphatase And Actin Regulator 1 (PHACTR1)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphatase And Actin Regulator 1 (PHACTR1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Phosphatase And Actin Regulator 1 (PHACTR1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Phosphatase And Actin Regulator 1 (PHACTR1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Phosphatase And Actin Regulator 1 (PHACTR1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Phosphatase And Actin Regulator 1 (PHACTR1)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphatase And Actin Regulator 1 (PHACTR1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Phosphatase And Actin Regulator 1 (PHACTR1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Phosphatase And Actin Regulator 1 (PHACTR1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Phosphatase And Actin Regulator 1 (PHACTR1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Phosphatase And Actin Regulator 1 (PHACTR1)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphatase And Actin Regulator 1 (PHACTR1)ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis."Biochimie 93:1668-1675(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells."Cell. Signal. 24:214-223(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]