Polycystic Kidney Disease 2 Protein (PKD2)

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PC2; APKD2; TRPP2; PKD4; Transient Receptor Potential Cation Channel,Subfamily P,Member 2; Autosomal dominant polycystic kidney disease type II protein; Polycystwin

Polycystic Kidney Disease 2 Protein (PKD2)
Polycystin-2 is a member of the polycystin protein family, called TRPP1, previously known as polycystin-2, PC2 or APKD2. TRPP1 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP1 may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents.Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polycystic Kidney Disease 2 Protein (PKD2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polycystic Kidney Disease 2 Protein (PKD2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polycystic Kidney Disease 2 Protein (PKD2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polycystic Kidney Disease 2 Protein (PKD2)CLIA Kit Customized Service Offer
n/aELISA Kit for Polycystic Kidney Disease 2 Protein (PKD2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polycystic Kidney Disease 2 Protein (PKD2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polycystic Kidney Disease 2 Protein (PKD2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polycystic Kidney Disease 2 Protein (PKD2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polycystic Kidney Disease 2 Protein (PKD2)CLIA Kit Customized Service Offer
n/aELISA Kit for Polycystic Kidney Disease 2 Protein (PKD2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polycystic Kidney Disease 2 Protein (PKD2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polycystic Kidney Disease 2 Protein (PKD2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polycystic Kidney Disease 2 Protein (PKD2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polycystic Kidney Disease 2 Protein (PKD2)CLIA Kit Customized Service Offer
n/aELISA Kit for Polycystic Kidney Disease 2 Protein (PKD2)ELISA Kit Customized Service Offer
  1. "PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein."Science 272:1339-1342(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2)."Genomics 44:131-136(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2."Genomics 38:1-4(1996) [PubMed] [Europe PMC] [Abstract]
  5. "In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2."J. Biol. Chem. 275:32888-32893(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton."Proc. Natl. Acad. Sci. U.S.A. 97:4017-4022(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Polycystin channels and kidney disease."Trends Pharmacol. Sci. 22:543-546(2001) [PubMed] [Europe PMC] [Abstract]
  8. "A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1."Hum. Mol. Genet. 14:3249-3262(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis."J. Biol. Chem. 283:28305-28312(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2)."Am. J. Hum. Genet. 61:547-555(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Aberrant splicing in the PKD2 gene as a cause of polycystic kidney disease."J. Am. Soc. Nephrol. 10:2342-2351(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Seven novel mutations of the PKD2 gene in families with autosomal dominant polycystic kidney disease."Kidney Int. 56:28-33(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations."Nat. Genet. 25:143-144(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Four novel mutations of the PKD2 gene in Czech families with autosomal dominant polycystic kidney disease."Hum. Mutat. 19:573-573(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Genotype-renal function correlation in type 2 autosomal dominant polycystic kidney disease." J. Am. Soc. Nephrol. 14:1164-1174(2003) [PubMed] [Europe PMC] [Abstract]
  19. "PKD2 mutations in a Czech population with autosomal dominant polycystic kidney disease."Nephrol. Dial. Transplant. 19:1116-1122(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns."J. Mol. Med. 83:638-646(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Novel method for genomic analysis of PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease."Hum. Mutat. 30:264-273(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Novel PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease (ADPKD)."Nephrol. Dial. Transplant. 26:2181-2188(2011) [PubMed] [Europe PMC] [Abstract]