Transmembrane Protease, Serine 3 (TMPRSS3)

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DFNB10; DFNB8; ECHOS1; TADG12; Tumor-associated differentially-expressed gene 12 protein; Serine protease TADG-12

Transmembrane Protease, Serine 3 (TMPRSS3)
TMPRSS3 contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor associated gene that is overexpressed in ovarian tumors. Four alternatively spliced variants have been described, two of which encode identical products.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Transmembrane Protease, Serine 3 (TMPRSS3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Transmembrane Protease, Serine 3 (TMPRSS3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Transmembrane Protease, Serine 3 (TMPRSS3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Transmembrane Protease, Serine 3 (TMPRSS3)CLIA Kit Customized Service Offer
n/aELISA Kit for Transmembrane Protease, Serine 3 (TMPRSS3)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Transmembrane Protease, Serine 3 (TMPRSS3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Transmembrane Protease, Serine 3 (TMPRSS3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Transmembrane Protease, Serine 3 (TMPRSS3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Transmembrane Protease, Serine 3 (TMPRSS3)CLIA Kit Customized Service Offer
n/aELISA Kit for Transmembrane Protease, Serine 3 (TMPRSS3)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Transmembrane Protease, Serine 3 (TMPRSS3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Transmembrane Protease, Serine 3 (TMPRSS3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Transmembrane Protease, Serine 3 (TMPRSS3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Transmembrane Protease, Serine 3 (TMPRSS3)CLIA Kit Customized Service Offer
n/aELISA Kit for Transmembrane Protease, Serine 3 (TMPRSS3)ELISA Kit Customized Service Offer
  1. "Ovarian tumor cells express a novel multi-domain cell surface serine protease."Biochim. Biophys. Acta 1502:337-350(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness." Nat. Genet. 27:59-63(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of a new full length TMPRSS3 isoform and identification of mutant alleles responsible for nonsyndromic recessive deafness in Newfoundland and Pakistan."BMC Med. Genet. 5:24-24(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro."Hum. Mol. Genet. 11:2829-2836(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Novel missense mutations of TMPRSS3 in two consanguineous Tunisian families with non-syndromic autosomal recessive deafness."Hum. Mutat. 18:101-108(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Novel mutations of TMPRSS3 in four DFNB8/B10 families segregating congenital autosomal recessive deafness."J. Med. Genet. 38:396-400(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in the TMPRSS3 gene are a rare cause of childhood nonsyndromic deafness in Caucasian patients."J. Mol. Med. 80:124-131(2002) [PubMed] [Europe PMC] [Abstract]
  12. "A novel TMPRSS3 missense mutation in a DFNB8/10 family prevents proteolytic activation of the protein."Hum. Genet. 117:528-535(2005) [PubMed] [Europe PMC] [Abstract]