Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)

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FSGS2; TRP6; Transient receptor protein 6

Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)
TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).
Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum (St. John's Wort) are hyperforin and adhyperforin. These compounds are inhibitors of the reuptake of serotonin, norepinephrine (noradrenaline) and epinephrine (adrenaline), dopamine, gamma-aminobutyric acid (GABA), and glutamate, and they exert these effects by binding to and activating TRPC6. Activation of TRPC6 induces the entry of calcium (Ca2+) and sodium (Na+) into the cell, which results in the reuptake inhibition.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPF846Hu01Recombinant Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)SDS-PAGE; WB; ELISA; IP.
AntibodiesMAF846Hu21Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)WB, ICC, IHC-P, IHC-F, ELISA
PAF846Hu01Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEF846HuELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)CLIA Kit Customized Service Offer
n/aELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)CLIA Kit Customized Service Offer
n/aELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)ELISA Kit Customized Service Offer
  1. "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol."Nature 397:259-263(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22."Cytogenet. Cell Genet. 83:46-47(1998) [PubMed] [Europe PMC] [Abstract]
  3. "TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells."J. Biol. Chem. 275:23965-23972(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity."J. Biol. Chem. 278:47842-47852(2003) [PubMed] [Europe PMC] [Abstract]
  6. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
  7. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  9. "TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function."Nat. Genet. 37:739-744(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis."Science 308:1801-1804(2005) [PubMed] [Europe PMC] [Abstract]
  11. "TRPC6 mutations in children with steroid-resistant nephrotic syndrome and atypical phenotype."Clin. J. Am. Soc. Nephrol. 6:1626-1634(2011) [PubMed] [Europe PMC] [Abstract]