X-Ray Repair Cross Complementing 1 (XRCC1)

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RCC; DNA repair protein XRCC1

X-Ray Repair Cross Complementing 1 (XRCC1)
XRCC1 is a DNA repair protein.involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.Inhibition of XRCC1 phosphorylation by mutation of the CK2 phosphorylation sites or by preventing CK2 activity using a highly specific inhibitor ablated the rapid repair of cellular DNA single-strand breaks by XRCC1. These data identified a direct role for CK2 in the repair of chromosome DNA strand breaks and in maintaining genetic integrity.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant X-Ray Repair Cross Complementing 1 (XRCC1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for X-Ray Repair Cross Complementing 1 (XRCC1)CLIA Kit Customized Service Offer
n/aELISA Kit for X-Ray Repair Cross Complementing 1 (XRCC1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant X-Ray Repair Cross Complementing 1 (XRCC1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for X-Ray Repair Cross Complementing 1 (XRCC1)CLIA Kit Customized Service Offer
n/aELISA Kit for X-Ray Repair Cross Complementing 1 (XRCC1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant X-Ray Repair Cross Complementing 1 (XRCC1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for X-Ray Repair Cross Complementing 1 (XRCC1)CLIA Kit Customized Service Offer
n/aELISA Kit for X-Ray Repair Cross Complementing 1 (XRCC1)ELISA Kit Customized Service Offer
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  4. "XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair."Cell 104:107-117(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein."Ann. Neurol. 55:241-249(2004) [PubMed] [Europe PMC] [Abstract]
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  11. "XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage."Nucleic Acids Res. 34:32-41(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks."J. Biol. Chem. 282:19638-19643(2007) [PubMed] [Europe PMC] [Abstract]
  13. "APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks."Mol. Cell. Biol. 27:3793-3803(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "SIRT1 deacetylates APE1 and regulates cellular base excision repair."Nucleic Acids Res. 38:832-845(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the first BRCT domain of DNA-repair protein XRCC1."Submitted (JUN-2006) to the PDB data bank
  22. "Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK."Nucleic Acids Res. 37:1701-1712(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans."Cancer Res. 58:604-608(1998) [PubMed] [Europe PMC] [Abstract]
  24. "Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells."Carcinogenesis 21:965-971(2000) [PubMed] [Europe PMC] [Abstract]
  25. "The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction."Cancer Res. 62:152-155(2002) [PubMed] [Europe PMC] [Abstract]
  26. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]