Dedicator Of Cytokinesis 8 (DOCK8)
Dock8 was identified during a yeast two hybrid (YTH) screen for proteins that interact with the Rho family small G protein Cdc42.Subsequent northern blot analysis revealed high levels of Dock8 expression in the placenta, lung, kidney and pancreas as well as lower levels in the heart, brain and skeletal muscle.
Dock8 shares the same core domain arrangement as all other DOCK proteins, with a DHR2 domain which, in other proteins, contains GEF activity and a DHR1 domain known, in other proteins, to interact with phospholipids. In the YTH system Dock8 was reported to interact with both Rac1 and Cdc42. However, no stable interaction between Dock8 and these small G proteins was observed in a GST-pulldown assay.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Dedicator Of Cytokinesis 8 (DOCK8)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Dedicator Of Cytokinesis 8 (DOCK8)CLIA Kit Customized Service Offer
n/aELISA Kit for Dedicator Of Cytokinesis 8 (DOCK8)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Dedicator Of Cytokinesis 8 (DOCK8)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Dedicator Of Cytokinesis 8 (DOCK8)CLIA Kit Customized Service Offer
n/aELISA Kit for Dedicator Of Cytokinesis 8 (DOCK8)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Dedicator Of Cytokinesis 8 (DOCK8)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Dedicator Of Cytokinesis 8 (DOCK8)CLIA Kit Customized Service Offer
n/aELISA Kit for Dedicator Of Cytokinesis 8 (DOCK8)ELISA Kit Customized Service Offer
  1. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The region on 9p associated with 46,XY sex reversal contains several transcripts expressed in the urogenital system and a novel doublesex-related domain."Genomics 64:170-178(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities."Genomics 91:195-202(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Combined immunodeficiency associated with DOCK8 mutations."N. Engl. J. Med. 361:2046-2055(2009) [PubMed] [Europe PMC] [Abstract]
  13. "20 ans apres: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition." Eur. J. Hum. Genet. 22:776-783(2014) [PubMed] [Europe PMC] [Abstract]