Forkhead Box Protein A3 (FOXA3)

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FOX-A3; HNF3G; TCF3G; Hepatocyte Nuclear Factor 3,Gamma; Fork head-related protein FKH H3

Forkhead Box Protein A3 (FOXA3)
FOXA3 encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved.
Mincheva et al. (1997) used fluorescence in situ hybridization to map the HNF3G gene to human chromosome 19q13.2-q13.4. By analysis of RFLPs in interspecific backcross mice, Avraham et al. (1992) mapped the mouse Hnf3-gamma gene to the proximal region of chromosome 7.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Forkhead Box Protein A3 (FOXA3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Forkhead Box Protein A3 (FOXA3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Forkhead Box Protein A3 (FOXA3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Forkhead Box Protein A3 (FOXA3)CLIA Kit Customized Service Offer
n/aELISA Kit for Forkhead Box Protein A3 (FOXA3)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Forkhead Box Protein A3 (FOXA3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Forkhead Box Protein A3 (FOXA3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Forkhead Box Protein A3 (FOXA3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Forkhead Box Protein A3 (FOXA3)CLIA Kit Customized Service Offer
n/aELISA Kit for Forkhead Box Protein A3 (FOXA3)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Forkhead Box Protein A3 (FOXA3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Forkhead Box Protein A3 (FOXA3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Forkhead Box Protein A3 (FOXA3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Forkhead Box Protein A3 (FOXA3)CLIA Kit Customized Service Offer
n/aELISA Kit for Forkhead Box Protein A3 (FOXA3)ELISA Kit Customized Service Offer
  1. "Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells."Blood 81:2854-2859(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis."Hum. Hered. 50:370-381(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation."Biochemistry 36:14096-14106(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma."Mol. Pharmacol. 63:1180-1189(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq."Genome Biol. 10:R129.0-R129.0(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of the CYP3A4 and CYP3A7 promoters by members of the nuclear factor I transcription factor family."Mol. Pharmacol. 76:1104-1114(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5."Nature 364:412-420(1993) [PubMed] [Europe PMC] [Abstract]