Corin (CRN)

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ATC2; CRN; Lrp4; TMPRSS10; Atrial Natriuretic Peptide-Converting Enzyme, Serine Protease; Heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme

Corin (CRN)
Corin encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.
The corin cDNA encodes a deduced 1,042-amino acid, type II transmembrane protein. At its N terminus, corin contains a short cytoplasmic domain and a transmembrane sequence. In the extracellular region of corin, there are 2 frizzled-like cysteine-rich motifs, 7 low density lipoprotein receptor repeats, a macrophage scavenger receptor-like domain, and a trypsin-like protease domain at the C terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG316Hu01 Recombinant Corin (CRN) Positive Control; Immunogen; SDS-PAGE; WB.
RPG316Hu02 Recombinant Corin (CRN) Positive Control; Immunogen; SDS-PAGE; WB.
RPG316Hu03 Recombinant Corin (CRN) Positive Control; Immunogen; SDS-PAGE; WB.
RPG316Hu04 Recombinant Corin (CRN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG316Hu01 Polyclonal Antibody to Corin (CRN) WB; IHC; ICC; IP.
MAG316Hu21 Monoclonal Antibody to Corin (CRN) WB; IHC; ICC; IP.
PAG316Hu02 Polyclonal Antibody to Corin (CRN) WB; IHC; ICC; IP.
PAG316Hu03 Polyclonal Antibody to Corin (CRN) WB; IHC; ICC; IP.
PAG316Hu04 Polyclonal Antibody to Corin (CRN) WB; IHC; ICC; IP.
Assay Kits SEG316Hu ELISA Kit for Corin (CRN) Enzyme-linked immunosorbent assay for Antigen Detection.
CEG316Hu ELISA Kit for Corin (CRN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG316Mu01 Recombinant Corin (CRN) Positive Control; Immunogen; SDS-PAGE; WB.
RPG316Mu02 Recombinant Corin (CRN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG316Mu01 Polyclonal Antibody to Corin (CRN) WB; IHC; ICC; IP.
PAG316Mu02 Polyclonal Antibody to Corin (CRN) WB; IHC; ICC; IP.
Assay Kits SEG316Mu ELISA Kit for Corin (CRN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG316Ra01 Recombinant Corin (CRN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG316Ra01 Polyclonal Antibody to Corin (CRN) WB; IHC; ICC; IP.
LAG316Ra71 Biotin-Linked Polyclonal Antibody to Corin (CRN) WB; IHC; ICC.
MAG316Ra21 Monoclonal Antibody to Corin (CRN) WB; IHC; ICC; IP.
Assay Kits SEG316Ra ELISA Kit for Corin (CRN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart."J. Biol. Chem. 274:14926-14935(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Localization of the mosaic transmembrane serine protease corin to heart myocytes."Eur. J. Biochem. 267:6931-6937(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme."Proc. Natl. Acad. Sci. U.S.A. 97:8525-8529(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin."J. Biol. Chem. 278:52363-52370(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Role of glycosylation in corin zymogen activation."J. Biol. Chem. 282:27728-27735(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood."Clin. Chim. Acta 409:85-89(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Ectodomain shedding and autocleavage of the cardiac membrane protease corin."J. Biol. Chem. 286:10066-10072(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Human corin isoforms with different cytoplasmic tails that alter cell surface targeting."J. Biol. Chem. 286:20963-20969(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy."Nature 484:246-250(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss."Hum. Mutat. 29:130-141(2008) [PubMed] [Europe PMC] [Abstract]